卡前列素氨丁三醇辅助预防前置胎盘剖宫产产后出血的临床观察

目的观察卡前列素氨丁三醇辅助预防前置胎盘剖宫产产后出血的效果。方法将前置胎盘剖宫产产妇68例随机分为观察组和对照组各34例。对照组剖宫产术中胎儿娩出后即在子宫体部注射缩宫素20U及口服米索前列醇0.4mg;观察组胎儿娩出后,即在子宫体部注射卡前列素氨丁三醇250μg和缩宫素20U。观察2组术中、术后2h及术后2～24h出血量和产后出血发生率以及药物不良反应。结果观察组术中、术后2h及术后2～24h出血量均少于对照组,产后出血率低于对照组,差异均有统计学意义(P<0.05)。2组均未出现严重不良反应。结论卡前列素氨丁三醇防治前置胎盘剖宫产产后出血安全有效,值得临床推广应用。

Clinical onservation of romethamine in accessory prevention of cesarean section postpartum hemorrhage of placenta previa

Objective To observation the effect of romethamine in prevention of cesarean section postpartum hemorrhage of placenta previa. Methods 68 cases maternals of cesarean section placenta previa were randomly divided into observa- tion group and control group, each of 34 cases. Control group received uterine body injection of oxytocin 20U and oral misopros- tol 0.4mg;Observation group received uterine body injection romethamine 2501xg and oxytoein 20U. Observed postoperative 2h and postoperative 2 N 24h the amount of bleeding and the incidence of postpartum hemorrhage and adverse drug reaction of two groups. Results The amount of bleeding of postoperative 2h and postoperative 2 - 24h in observation group were less than those in control group, the rate of postpartum hemorrhage was lower than that in control group, there were significant difference （ P 〈 0.05）. Two groups were no severe adverse reaction happened. Conclusion Romethamine in prevention of cesarean sec- tion postpartum hemorrhage of placenta previa is safe and effective, and worthy of clinical application.