化湿和化瘀法治疗冠心病的临床观察

目的：阐明湿和瘀间的关系。方法：本研究选择多年生活在岭南地区的痰湿证和血瘀证冠心病患者各１２８例、６９例,分别用化湿法和化瘀法治疗。结果：（１）痰湿证和血瘀证患者在血液流变学、氧自由基、血脂和血管活性物质方面有类似的变化。（２）两法均能缓解冠心病心绞痛,有效率为８８．３％和８９．９％,能改善心电图缺血表现及减少硝酸甘油用量（Ｐ〈０．００１）,改善血液流变学异常（Ｐ〈０．００１）,并能升高前列环素（

Clinical Study of Eliminating Dampness and Removing Blood Stasis in Treating Coronary Heart Disease-The Summary about Serial Study of Blood Stasis Due to Dampness

OBJECTIVE: To elucidate the relationship between Dampness and blood stasis in patients with coronary heart disease (CHD). METHODS: One hundred and twenty-eight CHD patients with Phlegm-Dampness Syndrome (PDS) and 69 with blood stasis syndrome (BSS) were chosen and treated by eliminating Dampness and removing blood stasis. RESULTS: (1) CHD-PDS and -BSS possessed the similar changes on hemorheology, oxygen free radical, blood lipids and vascular active substance. (2) Both of these two methods could alleviate angina (effective rate was 88.3%, 89.9%), improve ischemic S-T segment changes in ECG obviously and reduce consumption of nitroglycerin significantly (P < 0.01), improve abnormal hemorheology obviously (P < 0.001), raise PGI2, SOD obviously (P < 0.01) and lowered TXA2, MDA, ANP, ET and blood lipids significantly (P < 0.001). (3) The two methods could regulate imbalanced state of PGI2/TXA2,SOD/MDA. CONCLUSIONS: CHD-PDS and -BSS had similar pathologic basis or pathologic changes, could eliminate the Dampness also had possessed similar pharmacologic or pharmacodynamic action of removing blood stasis. According to this, the viewpoint of "blood stasis due to Dampness" might be proved from clinical aspect.