复方丹参对冠心病患者红细胞膜磷脂成分的影响

目的：探讨磷脂代谢在冠心病发病中的作用以及复方丹参对其影响。方法：采用薄层色谱扫描法和荧光法测定冠心病（ＣＨＤ）患者红细胞膜磷脂各成分以及过氧化脂质（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）含量及复方丹参治疗后上述各项指标的改变。结果：冠心病患者红细胞膜磷脂成分中的神经磷脂（ＳＭ）、磷脂酰丝氨酸（ＰＳ）、磷脂酰乙醇胺（ＰＥ）和溶血磷脂（ＬＬ）增高，磷脂酰胆碱（ＰＣ）较

Effect of Salvia Miltiorrhizae Composita on Erythrocyte Membrane Phospholipid in Patients with Coronary Heart Disease

To investigate the function of phospholipid metabolism in pathogenesis of coronary heart disease (CHD) and the effect of Salvia miltiorrhizae Composita (SMC) on it. Methods: The levels of erythrocyte membrane phospholipid, blood lipid peroxide (LPO ), superoxide dismutase (SOD)and glutathione peroxidase (GSH-Px) were determined in the patients with CHD by Thinlayer chromatography and fluorimetry during the treatment of SMC. Results: Sphingomyelins(SM),phosphatidyl serine (PS ), phosphatidyl ethanolamine (PE ) and lysophosphatide (LL ) of erythrocyte membrane phospholipid were increased in patients with CHD. Phosphatidyl cholines (PC)was lower than control group. Among them,the ratios of SM/PC and PS/PC were significantly higher. In the patients with CHD, LPO was significantly increased and ratios of SOD/LPO and GSH-Px/LPO significantly decreased. After the treatment with SMC, LL, SM, PS and PE of erythrocyte phospholipid and the ratios of SM/PC and PS/PC and LPO were decreased. PC and SOD/LPO were increased. Conclusions: The abnormality of erythrocyte membrane phospholipid participate the occurrence and development of CHD. SMC might improve the abnormality of erythrocyte phospholipid and lipid peroxide and possess the effect of regulating phospholipid metabolism.