青蒿琥酯片不同疗程治疗恶性疟疾疗效比较

观察青蒿琥脂片不同疗程治疗恶性疟疾的疗效。采用青蒿琥酯片３天，５天和７天疗程总量４００ｍｇ、６００ｍｇ和８００ｍｇ，治疗恶性疟疾９０例。全部临床治愈。各组间平均退热时间、原虫转阴时间相似。２８天原虫复燃率３天疗程组为３９．３％（１１／２８例）、５天疗程组为６．９％（２／２９例）和７天疗程组为３．４％（１／２９例），５天疗程组与３天疗程组比较，％＾２＝８．４８９，Ｐ〈０．００５；７天组与３天组比较，

Comparison on Treatment of Falciparum Malaria with Different Courses of Artesunate Tablet

To assess the efficacy of Artesunate on falciparum malaria. Methods: A randomized controlled study on the treatment of 90 uncomplicated falciparum malaria patients was carried out with 400 mg of artesunate tablet as a total dose over 3 days, 600 mg over 5 days and 800 mg over 7 days. Results: All patients were cured. Fever clearance time (FCT)and parasite clearance time (PCT ) among the three groups were similar. Parasite recrudescence rate within 28 days was 39. 3% (11/28)in 3 day group, 6. 9% (2/29)in 5 day group and 3. 4 % (1/29) in 7 day group(comparing 5 day group with 3 day group,P<0. 005,comparing 7 day group with 3 day group, P<0. 005). Conclusion: It indicated that parasite recrudescence rate may be effectively decreased by prolonging treatment courses.