精油对5-氟脲嘧啶渗透大鼠皮肤的促进作用

以月桂氮艹卓酮为参照研究了桉叶油、薄荷油和松节油3种精油对5-氟脲嘧啶渗透大鼠皮肤的促进作用及其机理。3种精油均具有促渗效果,其中桉叶油的增渗约60倍,而薄荷油和松节油分别引起46倍和28倍的增加,通过蒸馏分级将桉叶油按沸点高低分为5个部分,随着沸点升高,促渗效果也提高。在真空条件下140℃时的组分增渗倍数为83倍,略低于月桂氮艹卓酮(89倍)。精油的促渗作用可能与改进药物在组织中的分配和改进药物在皮肤中的扩散有关,但以改善扩散为主。3种精油改善扩散的程度与月桂氮艹卓酮相近。高沸点的桉叶油组分有类似的促渗机理。

ENHANCINGEFFECTOFESSENTIALOILSONTHEPENETRATIONOF5┐FLUOROURACILTHROUGHRATSKI

Three essential oils as penetration enhancers for 5-fluorouracil(5-FU)were studiedusing excised rat skin,The oils used were euealyptljs, pepper mint and turpentine. AZone was used forcomparison,The enhancing effect of the oils was found to be less than that of azone, but all the oils usedenhanced the permeation of 5-FU, Eucalyptus oil was found to be the most activel eausing about 60 foldincrease,while peppermint and turpentine caused 46 and 28 fold increase,respectively.Eucalyptus oil wasfurther studied by grading it into 5 fractions according to difference in beiling points, It was found that theiractivities incrcased as their beiling point increased, With all enhancers increased partition coefficients wereobserved but the diffusion coefficient values obtained were comparati vely higher The mode of action ofthese accelerants may be described by combined processes of partition and diffusion,the diffusion processbeing dominant.