Lack of association between CYP1A1 polymorphism and Parkinson's disease in a Chinese population |
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| Authors: | D. K. Y. Chan G. D. Mellick D. D. Buchanan W. T. Hung P. W. Ng J. Woo R. Kay |
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| Affiliation: | (1) Department of Aged Care and Rehabilitation, Bankstown Hospital, Bankstown, NSW,, AU;(2) Department of Medicine, Princess Alexandra Hospital, Woolloongabba, Qld, and, AU;(3) Key University Research Strength in Health Technologies, University of Technology, Broadway, NSW, Australia, AU;(4) Department of Medicine and Geriatrics, United Christian Hospital, and, HK;(5) Department of Medicine, Chinese University of Hong Kong, Hong Kong, HK |
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| Abstract: | Summary. Apart from very few families who have a direct cause from genetic mutation, causes of most Parkinson's disease (PD) remain unclear. Many allelic association studies on polymorphism of different candidate genes have been studied. Although these association studies do not imply a causal relationship, it does warrant further studies to elucidate the pathophysiologic significance. CYP1A1 polymorphisms have been reported to be associated with PD in a Japanese population sample. Since CYP1A1 transforms aromatic hydrocarbons into products that may be neurotoxic and perhaps lead to PD, we therefore undertook a study to look at the possible association of CYP1A1 polymorphism and PD in a Chinese population. Contrary to the Japanese result, we did not find any statistically significant difference between the PD group and the control group in our study with a bigger sample size. Received April 30, 2001; accepted September 4, 2001 |
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| Keywords: | : Parkinson's disease polymorphism CYP1A1 candidate gene. |
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