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新鲜乳腺疾病组织C-erbB-2基因蛋白表达、癌胚抗原、性激素受体的研究
引用本文:徐薇苓,刘尚廉,张廷 ,杨玉妹,李小妹. 新鲜乳腺疾病组织C-erbB-2基因蛋白表达、癌胚抗原、性激素受体的研究[J]. 肿瘤, 1994, 0(1)
作者姓名:徐薇苓  刘尚廉  张廷   杨玉妹  李小妹
作者单位:上海医科大学肿瘤医院病理科
摘    要:应用ABC法对42例乳腺癌、40例乳腺良性病变新鲜冰冻组织进行了C-erbB-2基因蛋白表达的研究,比较了C-erbB-2、雌激素受体(ER)、孕激素受体(PgR)、癌胚抗原(CEA)在乳腺癌组织中的表达。结果:乳腺癌中26例(61.9%)有C-erbB-2基因表达,强阳性表达8例(19.0%),良性乳腺病变也有表达;淋巴结转移多见于C-erbB-2阳性、ER阴性,CEA阴性病例;随着C-erbB-2表达程度增加(-→+→++),淋巴结转移阳性率增加,临床分期为I期的患者数减少,II、III期增多,ER、PgR受体水平下降。提示,C-erbB-2基因蛋白表达与预后有关,表达强度越高,预后越差。

关 键 词:C-erbB-2基因蛋白;乳腺癌;CEA;ER;PgR

IMMUNOHISTOCHEMICAL STUDY OF C-erbB-2,CEA AND STEROID RECEPTORS IN FRESH FROZEN SECTIONS OF BREAST LESIONS
Xu Wei-ling,Liu Shang-lian, Zhang Ting-qiu et al.. IMMUNOHISTOCHEMICAL STUDY OF C-erbB-2,CEA AND STEROID RECEPTORS IN FRESH FROZEN SECTIONS OF BREAST LESIONS[J]. Tumor, 1994, 0(1)
Authors:Xu Wei-ling  Liu Shang-lian   Zhang Ting-qiu et al.
Abstract:By using ABC method and frozen section of fresh breast lesion tissue, 26/42(61.9%)cases with breast cancer showed a positive expression of C-erbB-2 oncogene product, while 40 cases with benign breast lesions gave a positive rate of 47.5% (19/40). Reactivities of estrogen receptor(ER), progesterone receptor(PgR) and carcinoembryonic antigen (CEA) were more frequently seen in benign lesions (P<0. 05).Cases with lymphnode metastasis often had a positive C-erbB-2 and negative ER and CEA; increase of C-erbB-2 expression often accompanied by the increase of lymphnode metastatic rate. The result indicates that the expression of C-erbB-2 is related to prognosis, a strong expression means bad prognosis.
Keywords:C-erbB-2 oncogene product  Breast cancer  CEA  ER  PgR  
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