| 脑复清胶囊对D-半乳糖致痴呆小鼠脑胆碱能系统的影响 |
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| 引用本文： | 刘超,吴静,王静,杨军.脑复清胶囊对D-半乳糖致痴呆小鼠脑胆碱能系统的影响[J].中国中医药信息杂志,2004,11(2):129-130. |
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| 作者姓名： | 刘超 吴静 王静 杨军 |
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| 作者单位： | 1. 安徽省医学科学研究所,安徽,合肥,230061
2. 解放军第105医院,安徽,合肥,230061 |
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| 摘 要： | 目的观察脑复清胶囊对D-半乳糖致痴呆模型小鼠脑组织中乙酰胆碱酯酶和胆碱乙酰转移酶的影响.方法采用D-半乳糖造成小鼠痴呆模型,连续给药60d后,测定脑组织中乙酰胆碱酯酶和胆碱乙酰转移酶活性.结果脑复清胶囊可显著降低痴呆模型小鼠脑组织中乙酰胆碱酯酶活性,提高痴呆模型小鼠脑组织中胆碱乙酰转移酶活性.结论脑复清胶囊可能通过改善中枢胆碱能系统功能障碍来增强学习记忆能力.
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| 关 键 词： | 脑复清胶囊 D-半乳糖 痴呆 乙酰胆碱酯酶 胆碱乙酰转移酶 |
| 文章编号： | 1005-5304(2004)02-0129-02 |
| 修稿时间： | 2003年5月29日 |
Effects of Naofuqing Capsule on Cholinergic System in Demented Mice Induced By D-galactose |
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| LIU Chao,WU Jing,WANG Jing,et al.Effects of Naofuqing Capsule on Cholinergic System in Demented Mice Induced By D-galactose[J].Chinese Journal of Information on Traditional Chinese Medicine,2004,11(2):129-130. |
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| Authors: | LIU Chao WU Jing WANG Jing |
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| Institution: | LIU Chao1,WU Jing2,WANG Jing1,et al |
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| Abstract: | Objective To observe the effects of Naofuqing capsule on the activities of acetylcholinesterase and cholineacetyltransferase from brains in demented mice induced by D-galactose. Methods Demented mice induced by D-galactose were used and activities of acetylcholinesterase and cholineacetyltransferase from brains was determined. Results Naofuqing capsule could significantly decrease the activity of acetylcholinesterase and improve the activity of cholineacetyltransferase from brains in the demented mice. Conclusion Naofuqing capsule could improve the learning and memory ability through improving the dysfunction of cerebral cholinergic system. |
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| Keywords: | Naofuqing capsule D-galactose dementia acetylcholinesterase cholineacetyl-transferase |
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