| 姜黄素对TNF—α诱导人脐静脉内皮细胞产生NO及表达ICAM-1的影响 |
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| 引用本文： | 邬武斌,陈加才,陆曹杰. 姜黄素对TNF—α诱导人脐静脉内皮细胞产生NO及表达ICAM-1的影响[J]. 中国现代医生, 2011, 49(17): 9-10 |
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| 作者姓名： | 邬武斌 陈加才 陆曹杰 |
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| 作者单位： | 奉化市人民医院心内科,浙江奉化,315500 |
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| 摘 要： | 目的探讨姜黄素对TNF—α诱导人脐静脉内皮细胞产生NO以及表达ICAM-1的影响。方法体外培养人脐静脉内皮细胞，用10ng／mLTNF—α刺激后，再加入（5～40）μg／mL姜黄素共同孵育lh，采用MTT和ELISA法检测姜黄素对内皮细胞的增殖以及N0和ICAM-1的表达。结果（5～40）μg／mL姜黄素处理HUVEC细胞后，能明显抑制ICAM-1的表达，并增加NO的产生，呈剂量依赖性。结论姜黄素通过抑制内皮细胞ICAM-1的表达，促进NO的分泌，从而发挥内皮细胞保护作用以及抗动脉粥样硬化。
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| 关 键 词： | 姜黄素 人脐静脉内皮细胞 一氧化氮 细胞问黏附分子-1 |
Effect of Curcumin on HUVECs Production of NO and Expression of ICAM-1 |
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| WU Wubin,CHEN Jiacai,LU Caojie. Effect of Curcumin on HUVECs Production of NO and Expression of ICAM-1[J]. , 2011, 49(17): 9-10 |
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| Authors: | WU Wubin CHEN Jiacai LU Caojie |
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| Affiliation: | WU Wubin CHEN Jiacai LU Caojie Fenghua City People's Hospital,Fenghua 315500,China |
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| Abstract: | [Abstract] Objective To study the effect of cnrcumin on HUVECs production of NO and expression of ICAM-1. Methods The HUVECs were cultured in vitro and stimulated by 10ng/mL TNF-α , then incubated with （5 - 40 ） μg/mL of curcumin for lh. MTT and ELISA was used to detect NO and ICAM-1 production. Results ICAM-1 expression was inhibited by （5 - 40）μg/mL of curcumine, and increased NO production in dose-dependent manner. Conclusion Curcumin exhibit cytoprotection and antiartherosclerosis effect may mediated by inhibition of ICAM-1 expression and NO production. |
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| Keywords: | Curcumin Human umbilical vein endothelial cells Nitrogen monoxidum Intercellular adhesion molecule-1 |
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