高原老年男性性激素的变化研究

目的 :研究高原老年男性血清睾酮 (T)与雌二醇 (E2 )演变的特征。　方法 :按照居住在 310 0m高原的年限 ,90例老年男性 ,年龄在 6 0～ 76岁 ,分为 3组 :组 1(高原居住 1年 ,n =30 ) ;组 2 (高原居住 2年 ,n =30 ) ;组 3(高原本地老年居民 >10年 ,n =30 ) ,对照组 6 0例为年龄配伍的居住平原的老年居民。采用放射免疫技术分别测定血清T与E2水平和T/E2比值。　结果 :组 1、组 2和组 3的T、E2和T/E2比值分别为 42 .2± 38.5、70 .0± 31.5、190 .3± 73.5 ,44 .0± 42 .2、6 0 .6± 2 8.3、144 .9± 6 2 .0和 0 .96± 0 .19、1.16± 0 .11、1.33± 0 .2 4。组 3和T、E2和T/E2比组 1、组 2有极显著增高 (P <0 .0 0 1)。　结论 :高原老年男性的性激素水平随居住年限而增加。

Experimental Study on Changes of Sexual Hormones in Senior Males Living on High Altitude

OBJECTIVES: To investigate the characteristics of testosterone (T) and estradiol (E2) in senior males living on high altitude METHODS: According to the years of living on 3,100-meter high altitude. 90 senior males who were more than sixty years old were divided into three groups: group 1 (one year on the high altitude, n = 30), group 2 (two years on the high altitude, n = 30) and group 3 (over 10 years on the high altitude, n = 30). Additionally, there was a control group (living on the sea level). Radioimmunoassay technique was used to measure the level of T and E2 in their serum respectively. At the same time, the ratio of T/E2 was also examined. RESULTS: The levels of T, E2 and T/E2 of the three groups were 42.2 +/- 38.5, 70.0 +/- 31.5, 190.3 +/- 73.5 and 44.0 +/- 42.2, 60.6 +/- 28.3, 144.9 +/- 62.0 and 0.96 +/- 0.19, 1.16 +/- 0.11, 1.33 +/- 0.24, respectively. The levels of T, E2 and T/E2 of group 3 increased obviously than those of the other two groups (P < 0.01). CONCLUSIONS: The sexual hormone levels in senior males living on high altitude increase along with the living years.