α-突触核蛋白的生物学功能及其在帕金森病中的作用 |
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引用本文: | 熊中奎,胡雅儿.α-突触核蛋白的生物学功能及其在帕金森病中的作用[J].中国病理生理杂志,2010,26(9):1855-1858. |
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作者姓名: | 熊中奎 胡雅儿 |
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作者单位: | 1. 绍兴文理学院医学院临床医学部,浙江 绍兴 223000; 2. 上海交通大学医学院细胞调控实验室,上海 200025 |
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基金项目: | 绍兴文理学院重点科研资助项目 |
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摘 要: | α-Synuclein is identified as a constant component of dopaminergic neuronal pale eosinophilic inclusions "the Lewy bodies" in Parkinson’s disease. In fact, normal α-synuclein has lots of biological functions, which regulates synaptic plasticity, integrates presynaptic signaling, regulates dopamine level in the synapse, modulates microglial activation and lipid metabolism, and exerts heat shock protein-like function. However, abnormal α-synuclein leads to pathological lesion. Many studies show that pathological α-synuclein levels are elevated under the condition of its gene mutation, certain posttranslational modifications, dysfunction of molecular chaperones or ubiquitin proteasome system. The pathological α-synuclein plays an important role in neurodegeneration, in particular, Parkinson’s disease because it interrupts integrity of synaptic vesicles, ER-Golgi traffic and axonal transport, inhibits histone acetylation and chaperone-mediated autophagy, stabilizes itself against proteasomal degradation, and leads to neuroinflammation and abnormal phosphorylation of tau.
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关 键 词: | α-突触核蛋白 帕金森病 |
收稿时间: | 2009-8-29 |
修稿时间: | 2010-3-24 |
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