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Human type II collagen gene (COL2A1) assigned to chromosome 12q13.1-q13.2 byin situ hybridization with biotinylated DNA probe |
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| Authors: | Ei-ichi Takahashi Tada-aki Hori Jeanne B. Lawrence John McNeil Robert H. Singer Peter O'Connell Mark Leppert Ray White |
| Affiliation: | 1. Division of Genetics, National Institute of Radiological Sciences, Anagawa, 260, Chiba, Japan 2. Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue, 01655, North Worcester, Massachusetts, USA 3. Howard Hughes Medical Institute, University of Utah Medical Center, 603 wintrobe Building, 84132, Salt Lake City, Utah, USA |
| Abstract: | We have made a regional assignment of the type II collagen gene (COL2A1) on human chromosome 12 by means of anin situ hybridization technique with a biotinylated DNA probe. The precise localization of the signal was mapped to the band 12q13.1-q13.2. This result was in agreement with the previous mapping by isotopicin situ hybridization technique (12q13.1-q13.2), but not with the result of Southern hybridization analysis using somatic cell hybrids (12q14.3). |
| Keywords: | nonisotopicin situ hybridization chromosome mapping COL2A1 and chromosome 12 |
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