Prognostic significance of Ki-67, p53, and Bcl-2 expression in prostate cancer patients with lymph node metastases: A retrospective immunohistochemical analysis |
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Authors: | Mitsunobu Masuda Yasuo Takano Masayuki Iki Tomoyuki Asakura Takafumi Hashiba Sumio Noguchi Masahiko Hosaka |
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Affiliation: | Department of Urology, Yokohama City University School of Medicine, Yokohama, Japan;Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan;Department of Public Health, Kinki University School of Medicine, Osaka, Japan |
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Abstract: | The prognostic significance of Ki-67, p53, and Bcl-2 expression was evaluated in prostate cancer patients with lymph node metastases. Immunohistochemical staining of archived material obtained from 56 patients was performed by the streptavldin-biotin method. Univariate survival analysis showed that a Ki-67 labeling index (Ki-67 LI) of ≥8.4 in the primary tumor identified a group of patients with a significantly poorer prognosis (P<0.001). Furthermore, a Ki-67 LI of ≥8.7 in the nodal metastatlc tumor was also associated with a poorer prognosis (P<0.01). Multivariate analysis showed that the Ki-67 LI of primary tumors (P<0.01) and lymph node metastases (P<0.01) had independent prognostic value. p53 and Bcl-2 expression had no prognostic value in patients with prostate cancer and lymph node involvement. The Ki-67 LI has more prognostic value than p53 and Bcl-2 expression for patients with prostate cancer that has spread to the lymph nodes. |
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Keywords: | Bcl-2 immunohistochemistry Ki-67 p53 prostatic neoplasms |
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