| 国产洋红霉素对P388细胞单链DNA断裂及核仁超微结构的影响 |
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| 引用本文： | 颜江华 李常春. 国产洋红霉素对P388细胞单链DNA断裂及核仁超微结构的影响[J]. 癌症, 1993, 12(6): 506-509 |
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| 作者姓名： | 颜江华 李常春 |
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| 作者单位： | 福建医学院电镜室 350040厦门大学抗癌研究中心(颜江华),福建医学院电镜室 350040(李常春,黄自强),福建医学院药理教研室 福州(梁平) |
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| 摘 要： | 用碱洗脱技术观察了国产洋红霉素（ＤＭＮ）引起小鼠淋巴白血病Ｐ３８８细胞单链ＤＮＡ的断裂作用。在ＣＭＮ０．２５－２．０μｇ／ｍｌ范围内,这种作用是剂量依赖性的。电镜观察研究ＣＭＮ对Ｐ３８８细胞核仁超微结构的影响。ＣＭＮ１．０μｇ／ｍｌ作用２小时,核仁空泡增多、微球体出现;作用４小时,核仁仁空增多、微球体出现;作用４小时,核仁“帽”形成;作用８小时,部分细胞核仁成分碎裂。
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| 关 键 词： | 洋红霉素 核仁 超微结构 P388 |
EFFECTS OF DOMESTIC CARMINOMYCIN ON DNA SINGLE-STRAND BREAKS AND ON NEUCLEOLAR ULTRASTRUCTURAL CHANGES IN P_(388) CELLS |
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| YAN Jiang-hua LI Ghang-chun HUANG Zi-qiang Liang Ping. EFFECTS OF DOMESTIC CARMINOMYCIN ON DNA SINGLE-STRAND BREAKS AND ON NEUCLEOLAR ULTRASTRUCTURAL CHANGES IN P_(388) CELLS[J]. Chinese journal of cancer, 1993, 12(6): 506-509 |
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| Authors: | YAN Jiang-hua LI Ghang-chun HUANG Zi-qiang Liang Ping |
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| Abstract: | With alkaline elution assay, effects of domestic carminomycin on DNA single-strand breaks were observed in leukemia P388 cells. The effects were dose-dependent, timedepen dent and irreversible. Under electron microscope, it was obser/ced that carmino mycin caused a nucleolar "Cap" forming and a nucleolar segregation or fragmentation. |
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| Keywords: | carminomycin alkaline elution assay neucleolar ultrastrictire P388 |
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