Anti-cholinergic effect of Pluchea ovalis (pers.) Dc. (asteraceae) root extract on isolated Wistar rat tracheae |
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Authors: | Agbonon A Aklikokou K Kwashie E-G Gbéassor M |
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Institution: | Département de Physiologie/Pharmacologie, Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), Faculté des Sciences, Université de Lomé, Laboratoire JER 3006, B.P. 1515, Lomé Togo. |
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Abstract: | Ethanolic extract of Pluchea ovalis roots inhibit acetylcholine-induced bronchoconstriction observed in asthma. To understand the mechanism of P. ovalis root extract on airway smooth muscle contraction, we investigated the anti-cholinergic effect of the ethanolic extract on isolated isolated tracheae of the Wistar rat. For this purpose, three experimental conditions of incubation were used: idomethacin, indomethacin+propranolol or indomethacin+propranolo+ promethazine. The extract was applied in all three conditions at 0.25 mg/ml for 10 minutes prior to cumulative doses of acetylcholine (10(-8) to 5.10(-4) g/ml). The extract reduced acetylcholine-induced contraction and could have an antagonistic effect on muscarinic receptors of the rat trachea. |
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Keywords: | Anti-cholinergique Pluchea ovalis trachée artère Rat wistar |
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