The NOD2 receptor does not play a major role in the pathogenesis of Group B Streptococcus in mice |
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| Affiliation: | 1. National Cancer Institute, Cairo University, Giza, Egypt;2. Parasitology Department, Faulty of Medicine, Mansoura University, Mansoura, Egypt;3. Hygiene Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt;4. Virology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef 62511, Egypt;5. Microbiology Department, Virology Division, College of Medicine, Taif University, Al-Taif 21944, Saudi Arabia;1. Division of Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, Va; Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Md;2. Department of Statistics, Colorado State University, Fort Collins, Colo;3. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children''s Hospital of Philadelphia, Philadelphia, Pa;4. Division of Gastroenterology, University of North Carolina School of Medicine, Chapel Hill, NC;5. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md;6. Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md;7. Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC;1. Aix-Marseille University, Unité de Recherche sur les Maladies Infectieuses Transmissibles et Emergentes, UMR 63, CNRS 7278, IRD 198, INSERM U1095, Marseille, France;2. Inserm UMR 1068, Centre de Recherche en Cancérologie de Marseille, Marseille, France;1. Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;2. Department of Gastroenterology, Second Hospital of Gansu Province, Lanzhou 730000, China;1. Dept. of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, J&K 190011, India;2. Dept. of Gastroenterology, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Kashmir, J&K 190011, India;3. Dept. of General Surgery, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Kashmir, J&K 190011, India |
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| Abstract: | Group B Streptococcus (GBS) capsular type III is an important agent of life-threatening invasive infections. It has been previously shown that encapsulated GBS is easily internalized by dendritic cells (DCs) and this internalization has an impact on cytokine production. The intracellular receptors or pathways underlying this response are not well understood. In this work, we investigated the role of NOD2 in the pathogenesis of GBS using a mouse model of infection. NOD2−/− mice showed similar levels of survival and bacteremia than control mice. Interestingly, ex vivo analysis of total spleen cells from infected animals showed that the absence of NOD2 results in reduced production of inflammatory cytokines. However this abridged inflammatory response does not seem to improve mouse survival. In conclusion, we demonstrated that NOD2 is not a crucial receptor to fight GBS infection and only partially contributes to the inflammatory response. |
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| Keywords: | Pathogenesis NOD2 Inflammatory cytokines GBS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" Group B " },{" #name" :" italic" ," _" :" Streptococcus CPS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" capsular polysaccharide DCs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" dendritic cells TLR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" toll-like receptor NLRs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" nod-like receptors NOD1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" nucleotide-binding oligomerization domain-containing protein 1 NOD2" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" nucleotide-binding oligomerization domain-containing protein 2 NLRP3" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" NLR family pyrin domain-containing protein 3 |
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