骨髓红系造血岛的形态观察及其临床意义

目的 探讨骨髓红系造血岛(erythroblastic islands，EI )在血液病诊断和治疗中的意义。方法 以形态学方法观察309例骨髓涂片的EI。并且计数阳性率及判定成熟度。结果 EI阳性率最高的是：急性红血病、急性红白血病、良性嗜血组织细胞增多症，分别为75％、70％、63．6％；而再生障碍性贫血、急性白血病(除M6外)、淋巴瘤最低，未见到EI，白血病缓解后EI阳性率增加，达到43．7％。EI成熟度：急性红血病、急性红白血．病及骨髓增生异常综合征以早期EI为主；其余以晚期为主。结论 EI在某些贫血、良恶性嗜血组织细胞增多症的鉴别、白血病疗效的判断方面有重要的临床意义。

The examination of bone marrow erythroblastic islands and it′s clinical value

Objective To investigate the correlation between the morphological features of erythroblastic islands (EI) and clinical outcome. Methods The incidence and maturity of EI were measured by morphological examination.Results The incidence of EI was highest in acute erythremia, acute erythroleukemia, and iron deficiency anemia (75.0%?70.0%?63.6%, respectively), while very rare in aplastic anemia, acute leukemia (acute erythroleukemia excepted ), lymphoma. In addition, EI incidence in leukemia was significantly higher after remission than at presentation (43.7% vs 0, P<0.05). The number of immature EI in acute erythremia, acute erythroleukemia were higher than that of in others. Conclusion The examination of EI play an important role in some anemia diagnosis; it can distinguish malignant HPS from benign HPS and reflect the prognosis of leukemia.