Electron microscopy and X-ray microanalyses of uterine epithelium from lead-injected mice in an experimental delay of implantation |
| |
Authors: | B Ove Nilsson Leif Ljung Mariann Wide |
| |
Institution: | (1) Department of Human Anatomy, Biomedical Centre, Box 571, S-75123 Uppsala, Sweden;(2) Institute of Zoology, Box 561, S-75122 Uppsala, Sweden |
| |
Abstract: | Mice in experimental delay of implantation were injected intravenously with 75 g · g–1 body weight of lead chloride, corresponding to a dose of lead of about 56 g · g–1 body weight. Delay of implantation was obtained by ovariectomy 3 days after mating followed by a depot dose of progesterone every fifth day. Electron microscopy showed that the uterine lumen, which was closed in control mice, was opened in lead-injected mice. This morphology suggested that lead caused an increase in uterine secretion. X-ray microanalysis of pyroantimonate precipitates in the uterine epithelium of injected mice demonstrated lead in the precipitates, suggesting that lead could have a direct effect on the function of the uterine epithelium and that lead also could be secreted into the uterine lumen and affect the blastocysts. |
| |
Keywords: | Mice Implantation Uterine epithelium Lead |
本文献已被 SpringerLink 等数据库收录! |
|