| “三阴”乳腺癌新辅助化疗前后BCSG1基因状况研究 |
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| 引用本文： | 何劲松,宋淑芬,陈伟财,王敏,吴恢升,王媛,吴家豪,关弘,王先明.“三阴”乳腺癌新辅助化疗前后BCSG1基因状况研究[J].岭南现代临床外科,2009,9(3):167-169,175. |
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| 作者姓名： | 何劲松 宋淑芬 陈伟财 王敏 吴恢升 王媛 吴家豪 关弘 王先明 |
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| 作者单位： | 1. 深圳大学第一附属医院、深圳市第二人民医院,乳腺外科,深圳,518035
2. 深圳大学第一附属医院、深圳市第二人民医院,病理科,深圳,518035 |
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| 基金项目： | 广东省医学科学技术研究基金，深圳市科技计划项目研究基金 |
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| 摘 要： | 目的 探讨乳腺癌特异基因（BCSG1）在“三阴”性乳腺癌新辅助化疗疗效评估中的价值。方法采用免疫组化S．P法和荧光定量PCR方法检测32例“三阴”性乳腺癌患者新辅助化疗（CEF方案）前后乳腺癌组织BCSG1的表达，比较化疗前后肿瘤体积的变化情况，分析新辅助化疗前后BCSG1蛋白表达与肿瘤形态学变化的关系。结果23例乳腺癌患者新辅助化疗后肿瘤体积均有明显缩小，病灶缓解率（CR＋PR）为84．4％；新辅助化疗后BCSG1mRNA表达水平亦明显低于化疗前（P〈O．05），BCSG1蛋白高表达率低于新辅助化疗前（P〈0．01）。结论BCSG1分子和蛋白水平在“三阴”性乳腺癌新辅助化疗后均明显降低，与新辅助化疗后疗效呈负相关（r=-0．584，P〈0．01），提示BCSG1可作为“三阴”乳腺癌新辅助化疗疗效的预测因子。
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| 关 键 词： | “三阴”乳腺癌 乳腺癌特异基因 新辅助化疗 |
Study on status of BCSG1 in breast tissue of triple-negative breast cancer patients before and after receiving neoadjuvant chemotherapy |
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| He Jinsong,Song Shufen,Chen Weicai,et al Center of Breast Diseases,Second Hospital of Shenzhen,First Affiliated Hospital of Shenzhen University,Shenzhen Guangdong.Study on status of BCSG1 in breast tissue of triple-negative breast cancer patients before and after receiving neoadjuvant chemotherapy[J].Lingnan Modern Clinics in Surgery,2009,9(3):167-169,175. |
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| Authors: | He Jinsong Song Shufen Chen Weicai Center of Breast Diseases Second Hospital of Shenzhen First Affiliated Hospital of Shenzhen University Shenzhen Guangdong |
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| Institution: | He Jinsong,Song Shufen,Chen Weicai,et al Center of Breast Diseases,Second Hospital of Shenzhen,First Affiliated Hospital of Shenzhen University,Shenzhen Guangdong 518035 |
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| Abstract: | Objective To study the value of Breast cancer-specific gene 1 (BCSG1) on evaluating the curative effect of neoadjuvant chemotherapy (NAC) for triple-negative breast cancer. Methods The expression of BCSG1 in cancer tissue was assayed by immunohistochemistry and RTPCR in 32 cases of triple-negative breast cancer patients before and after receiving NAC of CEF (cyclophosphamide,epirubicin and fluorouracil) regimen. The therapeutic response of NAC was evaluated by morphological and pathological observation. The... |
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| Keywords: | Triple-negative breast cancer Breast cancer-specific gene Neoadjuvant chemotherapy |
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