| 反复海马CA1区惊厥阈下电刺激致实验大鼠持续性临床下痫样放电研究 |
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| 引用本文： | 郑宇,王庆松,向阳.反复海马CA1区惊厥阈下电刺激致实验大鼠持续性临床下痫样放电研究[J].西南国防医药,2008,18(6). |
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| 作者姓名： | 郑宇 王庆松 向阳 |
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| 作者单位： | 1. 成都军区总医院神经内科,四川,成都,610083;第三军医大学研究生队,重庆,400038
2. 成都军区总医院神经内科,四川,成都,610083 |
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| 基金项目： | 四川省卫生厅资助项目 |
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| 摘 要： | 目的：通过海马CA1区惊厥阈下电刺激建立可持续较长时间、无明显惊厥行为的临床下痫样放电动物模型。方法：选用雄性SD大鼠25只，通过反复大鼠海马CA1区惊厥阈下电刺激，观察大鼠惊厥行为，纪录电刺激停止后1、3、7、14、30d时大鼠皮层脑电图改变。结果：采用刺激频率30Hz，波宽1ms，串长10S，刺激强度0．1mA，串隔5min，10次／d，连续刺激4d，最后一次电刺激后30d内，均可在大鼠皮层记录到稳定发放的散在或阵发性高幅尖波、棘波、棘慢波，而实验动物并无明显的惊厥行为表现（Racine0级）。结论：反复海马CA1区惊厥阈下电刺激可较长时间诱发实验动物出现无明显惊厥行为的临床下痫样放电。
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| 关 键 词： | 临床下痫样放电 海马 惊厥阈下电刺激 |
Study of persistent subclinical epileptiform discharges following repetitive subthreshold electrical stimulation to hippocampus CA1 region in rats |
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| ZHENG Yu,WANG Qing-song,XIANG Yang.Study of persistent subclinical epileptiform discharges following repetitive subthreshold electrical stimulation to hippocampus CA1 region in rats[J].Medical Journal of National Defending forces in Southwest China,2008,18(6). |
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| Authors: | ZHENG Yu WANG Qing-song XIANG Yang |
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| Institution: | ZHENG Yu1,2,WANG Qing-song1,XIANG Yang1 1.Department of Neurology,General Hospital of Chengdu Military Comm,,Chengdu,610083,China.2.Postgraduate Team,Third Military Medical University,Chongqing,400038,China. |
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| Abstract: | Objective:To establish an animal model of persistent subclinical epileptiform discharges(SEDs) induced by repetitive subthreshold electrical stimulation to hippocampus CA1 region without obvious seizure activity in rats.Methods:Electrical stimulation was given to the hippocampus CA1 region in 25 male Sprague Dawley(SD) rats.The seizure activity of experimental rats was evaluated by Racine scores,and electrocorticogram(ECOG) was recorded at 1,3,7,14 and 30 d after the last electrical stimulation.Results:The ... |
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| Keywords: | subclinical epileptiform discharges hippocampus subthreshold electrical stimulation |
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