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紫外分光光度法测定新斯的明片中新斯的明的含量
引用本文:罗文,谭群友,熊华蓉,赵春景,张景勍. 紫外分光光度法测定新斯的明片中新斯的明的含量[J]. 中国药房, 2011, 0(16): 1505-1506
作者姓名:罗文  谭群友  熊华蓉  赵春景  张景勍
作者单位:[1]重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室,重庆市400016 [2]第三军医大学大坪医院野战外科研究所胸外科中心,重庆市400042 [3]重庆医科大学附属第二医院,重庆市400010
基金项目:教育部博士点基金资助项目(20095503120008); 重庆市教育委员会科学技术研究项目(KJ090308); 重庆市首批高等学校优秀人才资助项目
摘    要:目的:建立测定新斯的明片中新斯的明含量的方法。方法:采用紫外分光光度法。以水为溶剂,在260nm波长下测定新斯的明的含量。结果:新斯的明检测浓度在80~560μg·mL-1范围内与吸光度线性关系良好(r=0.9999);平均回收率为100.7%,RSD=0.65%(n=9)。结论:该法操作简便、精密度好,结果可靠,可用于新斯的明片的含量测定。

关 键 词:紫外分光光度法  新斯的明  含量测定

Content Determination of Neostigmine Tablets by UV Spectrophotometry
LUO Wen,XIONG Hua-rong,ZHANG Jing-. Content Determination of Neostigmine Tablets by UV Spectrophotometry[J]. China Pharmacy, 2011, 0(16): 1505-1506
Authors:LUO Wen  XIONG Hua-rong  ZHANG Jing-
Affiliation:qing(Key Laboratory of Biochemical&Molecular Pharmacology,College Medicine Engineering Research Center,Chongqing Medical University,Chongqing 400016,China) TAN Qun-you(Thoracic Surgery Center,Institute of Field Surgery Research,Daping Hospital of Third Military Medical University,Chongqing 400042,China) ZHAO Chun-jing(The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
Abstract:OBJECTIVE:To establish the method for the content determination of neostigmine tablets.METHODS:The contents of neostigmine were determined at 260 nm with water as the solvent by UV spectrophotometry.RESULTS:The calibration curve of neostigmine was linear when its concentration range was from 80 to 560 μg·mL-1(r=0.999 9).The average recovery rate was 100.7%(RSD=0.65%,n=9).CONCLUSION:The method is easy to operate,highly accurate,reliable in results and can be used for the content determination of neostigmine tablets.
Keywords:UV spectrophotometry  Neostigmine  Content determination
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