| 不同促渗剂对马钱子碱贴剂体外透皮吸收的影响 |
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| 引用本文： | 祁艳,陈军,李磊,蔡宝昌. 不同促渗剂对马钱子碱贴剂体外透皮吸收的影响[J]. 中国药房, 2011, 0(3): 195-197 |
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| 作者姓名： | 祁艳 陈军 李磊 蔡宝昌 |
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| 作者单位： | 南京中医药大学江苏省中药炮制重,最实验室／国家中医药管理局中药炮制标准重点实验室,南京市210029 |
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| 基金项目： | 国家科技重大专项课题（2009ZX09103-342） |
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| 摘 要： | 目的:研究不同促渗剂对马钱子碱贴剂体外透皮促渗作用的影响.方法:采用不同浓度、不同种类促渗剂制备马钱子碱贴剂;采用改良Franz扩散池,以离体雄性大鼠皮肤为模型,通过高效液相色谱法测定药物浓度,拟合马钱子碱透皮吸收的累积透过量和透过速率.结果:以3%氮酮制备的马钱子碱贴剂具有较好的体外透过速率及累积透过量;促渗剂合用时...
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| 关 键 词： | 马钱子碱 贴剂 促渗剂 |
Effect of Different Penetration Enhancers on Transdermal Permeation of Brucine Patch in Vitro |
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| QI Yan,CHEN Jun,LI Lei,CAI Bao-chang. Effect of Different Penetration Enhancers on Transdermal Permeation of Brucine Patch in Vitro[J]. China Pharmacy, 2011, 0(3): 195-197 |
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| Authors: | QI Yan CHEN Jun LI Lei CAI Bao-chang |
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| Affiliation: | (Nanjing University of Traditional Chinese Medicine,Jiangsu Key Laboratory of Chinese Medicine Processing,State Key Laboratory of Standardization for Chinese Medicine Processing,State Administration of Traditional Chinese Medicine,Nanjing 210029,China) |
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| Abstract: | OBJECTIVE：To study the effect of different penetration enhancers on transdermal permeation of brucine patch in vitro.METHODS：Brucine patch was prepared with different concentration and type of penetration enhancers.Using modified Franz diffusion cell and excised male rat skin as model,the concentration of brucine was determined by HPLC.Accumulative permeation quantity and velocity constant of brucine were fitted.RESULTS：3% azone was used to prepare brucine patch which was characterized with sound accumulative permeation velocity and permeation quantity.3% azone combined with 3% menthol promoted the transdermal permeation of brucine patch,while 3% azone alone was the best.CONCLUSION：Brucine patch prepared by 3% azone has higher transdermal rate than others,combination of 3% azone and other penetration enhancers is not good for transdermal absorption of brucine. |
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| Keywords: | Brucine Patch Penetration enhancer |
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