复方苦参注射液预防急性放射性直肠炎的临床观察

目的:观察复方苦参注射液预防急性放射性直肠炎的疗效。方法:将2008年6月-2010年6月在长治医学院附属和平医院实行根治性放疗的89例Ⅱb～Ⅲb期宫颈癌患者随机分为复方苦参注射液联合放疗组(46例)和单纯放疗组(43例)。2组患者均实行常规根治性放疗(体外照射+腔内治疗)。联合用药组在放疗期间静脉应用复方苦参注射液,每次20mL,用200mL氯化钠注射液稀释后60min内静脉滴入,滴完25min内进行常规放疗,每天1次,每周5次,至放疗结束;单纯放疗组仅常规放疗。结果:联合用药组Ⅰ度放射性直肠炎发生率为10.87%,Ⅱ度放射性直肠炎发生率为4.35%,未见Ⅲ度放射性直肠炎发生;单纯放疗组Ⅰ、Ⅱ、Ⅲ度急性放射性直肠炎发生率分别为58.14%、30.23%、4.65%,2组比较有显著性差异(P<0.01);联合用药组、单纯放疗组平均放疗总时间分别为45.4d和50.1d,2组比较有显著性差异(P<0.05)。放疗结束3个月时,2组的有效率分别为84.8%、72.1%,2组比较无统计学差异(P>0.05)。结论:复方苦参注射液可有效预防急性放射性直肠炎的发生,且不影响肿瘤的近期疗效。

Clinical Observation of Compound Sophora flavescens Injection in the Prevention of Acute Radiation Proctitis

To observe the clinical efficacy of Compound Sophora flavescens injection in the prevention of acute radiation proctitis. METHODS： 89 patients with cervical carcinoma in our hospital, who received Ⅱb～Ⅲb stage of radical radiation therapy from June 2008 to June 2010, were randomized into drug combination group （46 cases） and single radiotherapy group （43 case）. Both groups received conventional radical radiation therapy （extracorporeal irradiation and intracavitary therapy）. Drug combination group received Compound S. flavescens injection 20 mL which was diluted with Sodium chloride injection 200 mL via i.v. gtt in 60 min, and radiotherapy was performed within 25 min once a day from Monday to Friday. Single radiotherapy group received conventional radiotherapy. RESULTS： The incidence rate of I grade of acute radiation poctitis in drug combination group was 10.87% and that of Ⅱ grade of acute radiation poctitis was 4.35%. Ⅲ grade of acute radiation proctitis was not observed. In single radiotherapy group, the incidence rates of Ⅰ ,Ⅱ and Ⅲ grade of acute radiation poctitis were 58.14%, 30.23% and 4.65%, respectively. There was significant difference between 2 groups （P〈0.01）. The duration of complete radiotherapy in drug combina- tion group and single radiotherapy group were 45.4 d and 50.1 d, there was significant difference between 2 groups （P〈0.05）. Three months after radiotherapy, the effective rate of both groups were 84.8% and 72.1% respectively, showing no significant difference （P〉0.05）. CONCLUSION： Compound S. flavescens injection is effective for the prevention of acute radiation proctitis, and doesn＇t affect short-term curative effect.