我院599例药品不良反应报告分析

目的:了解我院药品不良反应(ADR)发生的特点及规律以及临床药师在ADR监测工作中的作用。方法:对我院2009年上报的599例ADR报告,按患者情况、ADR级别、报告人、药品名称、给药途径、临床表现等项目进行统计、分析。结果:599例ADR报表中,新的严重的ADR报告155例(占25.88%);临床药师上报ADR报告327例(占54.59%);静脉给药引发的ADR为421例(占70.28%);引起ADR最常见的药为抗感染药,共314例(占52.42%);所累及的器官或系统以消化系统损害为主,有207例(占28.55%),其次为皮肤及其附件损害(156例,占21.52%)、心脑血管系统损害(112例,占15.45%)。结论:新的严重的报告在分析评价中有重要意义;临床药师在ADR监测工作中应发挥主要作用;应加强抗感染药的临床应用管理;ADR监测工作可以促进临床安全合理用药。

Analysis of 599 ADR Cases Reported in Our Hospital

OBJECTIVE： To investigate the characteristics and regularity of adverse drug reaction （ADR） in our hospital and the role of clinical pharmacists in ADR monitoring. METHODS： 599 ADR cases reports were collected in our hospital in 2009, which were analyzed statistically in respects of general information of patients, ADR degree, reporter, drug name, route of administration, clinical manifestation, etc. RESULTS： Of 599 ADR cases, there were 155 new serious ADR cases （25.88%） , 327 ADR cases （54.59%） were reported by clinical pharmacists. 421 （70.28%） were induced by intravenous route. 314 ADR cases were induced by anti-infective agents （52.42%）. Most of ADR occurred in digestive system in 207 cases, accounting for 28.55%, followed by lesion of skin and its appendants （156 cases, 21.52% ）, injury of cardiovascular and cerebral system （112 cases, 15.45% ）. CONCLUSION： Analysis of new serious ADR cases is of significance; clinical pharmacists play a major role in ADR monitoring. We should strengthen the management of anti-infective agents; ADR monitoring can improve rational use of drugs in the clinic.