Pharmacokinetics of E-5-(2-Bromovinyl)-2′-Deoxyuridine in Mice |
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| Authors: | E de Clercq J Descamps P de Somer P J Barr A S Jones and R T Walker |
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| Institution: | 1Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;2Department of Chemistry, University of Birmingham, Birmingham B15 2TT, Great Britain |
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| Abstract: | The pharmacokinetics of the newly developed anti-herpes agent, E-5-(2-bromovinyl)-2'-deoxyuridine, was compared with that of the standard anti-herpes drug 5-iodo-2'-deoxyuridine. Both compounds were administered to mice at 100 mg/kg by either the intraperitoneal, subcutaneous, or oral route. The active blood drug levels achieved by E-5-(2-bromovinyl)-2'-deoxyuridine were considerably higher than those attained by 5-iodo-2'-deoxyuridine (serum peak concentrations: 40 to 100 and 4 to 10 mug/ml, respectively). Active blood drug levels could still be found 320 min after oral administration of E-5-(2-bromovinyl)-2'-deoxyuridine. |
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