| 二苯噁丙酸的抗炎作用及其机理 |
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| 引用本文： | 尚雪原,张世玲,鲁凤友,焦波,程艳娜.二苯噁丙酸的抗炎作用及其机理[J].中国现代应用药学,1996(5):5-6. |
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| 作者姓名： | 尚雪原 张世玲 鲁凤友 焦波 程艳娜 |
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| 作者单位： | 山东医科大学药学系 |
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| 摘 要： | 以多种炎症模型观察了二苯丙酸的抗炎作用。给动物灌服二苯丙酸，能抑制角叉莱胶致足跖肿胀和棉球致内芽组织增生，对大鼠佐剂性关节炎也有明显的抑制作用。该药的抗炎作用强度与阿司匹林相似，但作用时间明显延长。探讨其作用机理表明，二苯丙酸能降低毛细血管通透性，抑制白细胞游走反应，但对血浆皮质醇的含量无明显影响。
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| 关 键 词： | 二苯丙酸 阿司匹林 抗炎作用 |
The Antinflammatory Activity of Oxaprozin and its Mechanism |
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| Shank Xue-yuan; Zhang Shi-ling; Lu Feng--you; Jiao Bo; Cheng Yan-na.The Antinflammatory Activity of Oxaprozin and its Mechanism[J].The Chinese Journal of Modern Applied Pharmacy,1996(5):5-6. |
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| Authors: | Shank Xue-yuan; Zhang Shi-ling; Lu Feng--you; Jiao Bo; Cheng Yan-na |
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| Abstract: | The antiinflammatory activity of oxaprozin in several inflammatory model wasobserved. The results showed that oxaprazin inhibited the exudative inflammation induced bycarrageenan and the granuloma tissue formation induced by cotton pellet. It also had inhibitory effect on adjuvant arthritis in rats. The antiinflammatory potency of oxaprozin was similarfo that of aspirin. But the former effects lasted longer. The antiinflammatory mechanism ofoxaprozin was also studied. The results indicated that oxaprozin reduced the capillary permibilityof mice and inhibited the migration of white cell. But it had no effects on plasma:corticosteroidcoment. |
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| Keywords: | oxaprozin aspirin antiinflammatory activity |
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