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Evaluation of alternative calculation methods for determining low-density lipoprotein cholesterol in hemodialysis patients |
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| Authors: | Bairaktari Eleni T Tzallas Christos Kalientzidou M Tselepis Alexandros D Siamopoulos Kostas C Seferiadis Konstantin I Elisaf Moses S |
| Institution: | Laboratory of Biochemistry, University Hospital, Medical School, University of Ioannina, 451 10, Ioannina, Greece. ebairakt@cc.uoi.gr |
| Abstract: | OBJECTIVES: To evaluate alternative equations for the estimation of low-density lipoprotein cholesterol (LDL-C) than the Friedewald equation in hemodialysis patients. DESIGN AND METHODS: The equations LDL-C = 0.41TC - 0.14TG + 0.66ApoB - 10.43 and LDL-C = 0.94TC - 0.94HDL-C - 0.19TG were evaluated in 86 patients and compared with the Friedewald equation and the ultracentrifugation procedure. RESULTS: The alternative equations yield significantly lower bias than the Friedewald equation and are less affected by increased triglycerides (TG) levels. CONCLUSION: The alternative equations for LDL-C yield slightly better results than the Friedewald equation especially in hypertriglyceridemia. |
| Keywords: | LDL-cholesterol calculation Friedewald equation Apolipoprotein B Method comparison Hemodialysis patients Small dense LDL |
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