| AMPK在内皮细胞中对血管形成的影响 |
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| 引用本文： | 杨宵曼,朱 伟,刘铭雅,等. AMPK在内皮细胞中对血管形成的影响[J]. 医学综述, 2014, 0(2): 215-217 |
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| 作者姓名： | 杨宵曼 朱 伟 刘铭雅 等 |
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| 作者单位： | 上海交通大学附属第六人民医院心内科,上海200233 |
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| 基金项目： | 上海市科委自然科学基金（10zr1422900） |
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| 摘 要： | 在真核细胞中,腺苷酸活化蛋白激酶(AMPK)是细胞及全身能量稳态的一个重要调节器,受体内AMP/ATP比率调节,通常被称为代谢敏感性激酶。新近的研究发现,AMPK的激活参与了许多细胞(如骨骼肌细胞、内皮细胞)的分化、迁移和管腔形成。该文就AMPK在血管生成这一生物效应中的显像和作用机制予以综述。
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| 关 键 词： | 腺苷酸活化蛋白激酶 内皮细胞 血管形成 内皮型一氧化氮合酶 |
The Effect of AMPK on Angiogenesis in Endothelial Cells |
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| Affiliation: | YANG Xiao-man, ZHU Wei, LIU Ming-ya, WEI Meng. (Division of Cardiology, the Sixth People＇s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China) |
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| Abstract: | The AMP-activated protein kinase（ AMPK）, as a metabolite-sensing kinase, is a key regulator of cellular and whole-body energy homeostasis which is tighdy regulated by the levels of AMP/ATP ratio. Recent studies indicate AMPK activation is also involved in the differentiation, migration and tube formation in a lot of ceils（ such as skeletal muscle cells, endothelial cells）. Here is to make a review of the recent advances in the roles and action mechanisms of AMPK in angiogenesis. |
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| Keywords: | AMP-activated protein kinase Endothelial ceils Angiogensis Endothelial nitric oxide syn- thase |
| 本文献已被 CNKI 维普 等数据库收录！ |
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