| Xp1区内定位注意缺损多动障碍易感位点的研究 |
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| 引用本文： | 江三多,忻仁娥,钱伊萍,林嗣萃,李飞,吴晓东,汪栋祥,汤国梅,江开达. Xp1区内定位注意缺损多动障碍易感位点的研究[J]. 中华医学遗传学杂志, 2001, 18(3): 169-172 |
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| 作者姓名： | 江三多 忻仁娥 钱伊萍 林嗣萃 李飞 吴晓东 汪栋祥 汤国梅 江开达 |
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| 作者单位： | 1. 上海市精神卫生中心达
2. Department of Anatomy and Neurobiology, Medical College of Ohio, |
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| 基金项目： | 国家自然科学基金(39970774) |
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| 摘 要： | 目的探讨注意缺损多动障碍(attentiondeficit hyperactivity disorder, ADHD)与单胺氧化酶(monoamine oxidase, MAO)A型基因的遗传关系。方法采用基于单体型相对风险(haplotype-basedhaplotype relative risk，HHRR)和传递不平衡检验(transmission disequilibrium test,TDT)的方法，在60个ADHD儿童和双亲中进行了MAOCA微卫星多态性的关联和连锁分析。结果经HHRR和TDT分析，ADHD儿童与MAOCA位点114bp相关联和连锁(χ2分别为4.90和4.84，P＜0.05)。结论 ADHD与MAO A型基因相关联和连锁，其易感位点可能定位于Xp1区。
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| 关 键 词： | 注意缺损多动障碍 单胺氧化酶基因 关联 连锁 易感位点 遗传分析 儿童 |
| 修稿时间： | 2000-06-22 |
Study of susceptibility loci located within Xp11 in attention deficit hyperactivity disorder |
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| JIANG Sanduo,XIN Rene,QIAN Yiping,LIN Sicui,LI Fei,WU Xiaodong,WANG Dongxiang,TANG Guomei,Jiang Kaida. Study of susceptibility loci located within Xp11 in attention deficit hyperactivity disorder[J]. Chinese journal of medical genetics, 2001, 18(3): 169-172 |
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| Authors: | JIANG Sanduo XIN Rene QIAN Yiping LIN Sicui LI Fei WU Xiaodong WANG Dongxiang TANG Guomei Jiang Kaida |
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| Affiliation: | Shanghai Mental Health Center, Shanghai 200030 P. R. China. |
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| Abstract: | OBJECTIVE: To detect the genetic relationship between monoamine oxidase(MAO) A type gene and attention deficit hyperactivity disorder(ADHD) in Chinese. METHODS: The haplotype-based haplotype relative risk(HHRR) and the transmission disequilibrium test(TDT) methods were used to analyze the genetic association and linkage in 60 ADHD children and their parents. RESULTS: In this sample were found significant association (chi(2)=4.90, P<0.05) and linkage (chi(2)=4.84, P<0.05) between the MAOCA 114bp allele and DSM-III-R-diagnosed ADHD in trios composed of father, mother and affected offspring. CONCLUSION: The above results suggested that ADHD was associated and in linkage with MAO A gene, and the susceptibility loci might reside in chromosome Xp11 for ADHD. |
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| Keywords: | attention deficit hyperactivity disorder monoamine oxidase gene association linkage |
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