Hydrolysed protein accelerates the gastrointestinal transport of formula in preterm infants |
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Authors: | Mihatsch W A Högel J Pohlandt F |
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Affiliation: | Department of Pediatrics, University of Ulm, Germany. |
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Abstract: | Vomiting, large gastric residuals and abdominal distension are common in very immature infants on formula feeding. The present trial investigated whether a protein hydrolysate formula reduces the gastrointestinal transit time in preterm infants. Fifteen preterm infants (median gestational age 29 (24-32) wk, birthweight 1241 (660-1900) g, postnatal age 18 (5-54) d) on full enteral feeds (>150 ml/kg*d) were enrolled. It was hypothesized that the gastrointestinal transit time is at least 2 h shorter when protein hydrolysate formula is fed compared with standard preterm formula. In a randomized cross-over design study, each formula was fed for 5 d. On days 4 and 9 the gastrointestinal transit time was estimated using carmine red. The protein hydrolysate formula had a markedly shorter gastrointestinal (p = 0.0022, two-sided Mann-Whitney U test). Conclusion: The hydrolysate protein formula accelerated gastrointestinal transit of milk and stools, but whether hydrolysate formulas enable a more rapid establishment of full enteral feeding in preterm infants needs to be investigated. transit time (9.8 h) than the standard formula (19 h) |
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Keywords: | Gastrointestinal Transit Time Infant Nutrition Preterm Infant Protein Hydrolysate Formula |
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