| 氯霉素控释眼丸的研究 |
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| 引用本文： | 曾德惠,曾志,向俭,马文秀,周永闸,陈先樵. 氯霉素控释眼丸的研究[J]. 药学学报, 1988, 23(11): 846-849 |
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| 作者姓名： | 曾德惠 曾志 向俭 马文秀 周永闸 陈先樵 |
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| 作者单位： | 西南制药三厂 重庆(曾德惠,曾志,向俭,马文秀,周永闸),西南制药三厂 重庆(陈先樵) |
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| 摘 要： | 氯霉素控释眼丸(以下简称眼丸)经体外、眼内试验可持续恒速释药10d,眼内释药量平均为13.35μg/h。眼丸是根据中药“龙虱子”设计,用滴丸工艺制成,于中央钻孔以达到恒速释药。制法简便、成本低、使用方便、安全、疗效可靠。
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| 关 键 词： | 限控释(给药)体系 氯霉素滴丸 控释系统 |
| 收稿时间： | 1987-03-27 |
STUDIES ON THE CHLORAMPHENICOL CONTROLLED RELEASE OCULAR SYSTEM |
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| DH Zeng,Z Zeng,J Xiang,WX Ma,YZ Zhou and XQ Chen. STUDIES ON THE CHLORAMPHENICOL CONTROLLED RELEASE OCULAR SYSTEM[J]. Acta pharmaceutica Sinica, 1988, 23(11): 846-849 |
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| Authors: | DH Zeng Z Zeng J Xiang WX Ma YZ Zhou XQ Chen |
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| Abstract: | The release of chloramphenicol from the ocular system attained a virtually constant rate of 13.35 μg/h in eyes, and maintained throughout 10 days. It was designed according to the traditional Chinese drug "Long Shi Zi", prepared by the method of pilulae with a perforation in its center. The advantages of chloramphenicol ocular system are: ease of insertion and removal and better resistant to expulsion by movement of the eye because of its small size; simplicity of production and low cost. No irritation or discomfort was observed in clinical trials on 300 patients. The therapeutic values are reliable. |
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| Keywords: | Ocular (therapeutic) systems: Chloramphenicol pilulae Controlledrelease system. |
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