1 Laboratory for Tumor Epigenetics and Stemness, National Institute of Cancer Research and Translational Center for Glandular Malignancies, National Health Research Institutes, Tainan, Taiwan;2 Department of Pathology, National Cheng-Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan;3 Department of Surgery, National Cheng-Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan;4 Department of Medicine, National Cheng-Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan;5 Department of Medical Education and School of Nursing, Chung Shan Medical University and Hospital, Taichung, Taiwan;6 Taiwan Bioinformatics Core, National Health Research Institutes, Zhunan, Taiwan;7 Pathology Core Laboratory, National Health Research Institutes, Tainan, Taiwan;8 Department of Information Engineering, Kun Shan University, Tainan, Taiwan;9 Graduate Institute of Clinical Medicine, School of Medicine, and Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University and Hospital, Taipei, Taiwan