Penetration of imipenem into human aqueous and vitreous humor |
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Authors: | J L Axelrod J C Newton R M Klein R L Bergen M Z Sheikh |
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Affiliation: | Division of Infectious Diseases and Epidemiology, St. Luke's-Roosevelt Hospital Center, New York, New York 10025. |
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Abstract: | Twenty-five patients about to undergo cataract surgery and ten patients about to undergo vitrectomy received a 1-g intravenous dose of imipenem before surgery. Specimens of aqueous or vitreous humor were then obtained and assayed for antibiotic content with a microbiologic disk agar technique. A mean peak aqueous humor level of 2.99 micrograms/ml was found at approximately two hours after administration, and a mean vitreous level of 2.53 micrograms/ml was found from two hours to three hours 15 minutes after administration. These concentrations were well above the minimum inhibitory concentration of imipenem for 90% (MIC90) of Staphylococcus epidermidis, S. aureus, and the Enterobacteriaceae commonly involved in bacterial endophthalmitis. |
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