NK细胞表面受体及其研究进展

自然杀伤(NK)细胞是体内重要的免疫效应细胞,因其杀伤肿瘤细胞不受主要组织相容性复合物(MHC)限制、具有实现移植物抗白血病(GVL)效应与移植物抗宿主病(GVHD)分离等优势,在肿瘤过继免疫治疗中占有重要地位。研究表明,NK细胞受体众多,分别传递抑制性或活化性信号,两者间的平衡是决定NK细胞功能状态的关键因素,这为优化NK细胞过继免疫治疗提供了新思路。基于此,对于NK细胞受体的研究一直是近年来的研究热点。本文就人类NK细胞受体及临床研究进展作一综述。

NK cell surface receptors and their research progress - review

Natural killer (NK) cells are important immune cells in human body, which occupy an important place in adoptive immunotherapy for patients with malignancies due to their capacity of killing tumor cells without MHC limitation, as well as seperating graft versus leukemia (GVL) and graft versus host disease (GVHD). Recent studies showed that different kinds of NK cell-surface receptors have been found, which transmit inhibiting signals or activating signals, the balance between them determines the functional status of NK cells. Researchers have focused on the study of NK cell-surface receptors recently in order to improve application of NK cells for adoptive immunotherapy. This review summaries the current advancement about NK cell-surface receptors and their clinical significance.