移民新建镇人群血吸虫抗体水平变化的观察

目的 通过血清学方法观察移民新建镇人群血吸虫抗体水平的变化。 方法 2002-2005年选择长江安徽段血吸虫病流行区退人又退耕的双退点、退人不退耕的单退点和未退人退耕的对照点各1个为试点，采用斑点金免疫渗滤法（DIGFA）与ELISA法纵向平行检测各试点人群血吸虫抗体水平。 结果 双退点DIGFA、ELISA测得的人群血吸虫抗体阳性率分别从2002年的6.63%、7.26%下降到2005年的3.52%和3.71%，差异均有统计学意义（χ²=5.2625，P<0.05；χ²=6.3296，P<0.05）；单退点和对照点人群的血吸虫抗体阳性率无显著变化。ELISA纵向检测3个试点人群血清血吸虫抗体的吸光度（A₄₅₀值）水平，经单因素方差分析，单退点2005年A₄₅₀均值为0.147，较2003年的0.182有显著下降（P<0.01）。双退点、对照点人群的血吸虫抗体均值无显著变化。 结论 移民新建镇人群血吸虫抗体阳性率及抗体水平呈不同程度的下降。

Observation on the Change of Anti-S.japonicum Antibody Level inPopulation Migrated from Outside Embankment to New Town

Objective To detect the change of the anti-S. japonicum antibody level after people migrated from outside embankment to newly established town. Methods Three pilot spots were established for the investigation: one spot thut both inhabitancy and cultivation disused (A), one spot that only inhabitancy disused but farming continued (B) and the third one served as control (C). DIGFA and ELISA were used to detect the antibody level in the populations from 2002 to 2005. Results The positive rate of anti-S.japonkum antibody declined significantly from 6.63% to 3.52% by DIGFA and from 7.26% to 3.71% by ELISA at spot A (X2=5.2625, P<0.05; X2=6.3296, P<0.05, respectively). There was no significant difference on the positive rate of antibody in spots B and C. The average A450 value of ELISA in the three spots was statistically analyzed by One-Way ANOVA. It was only in spot B that the average A450 value declined from 0.182 in 2003 to 0.147 in 2005 (P<0.01). Conclusion The anti-S.japonkum antibody level in human population has decreased at certain degree after they migrated from outside embankment to new town.