| 中药蜈蚣对小鼠胚胎发育的影响 |
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| 引用本文： | 虞国茂 沈康. 中药蜈蚣对小鼠胚胎发育的影响[J]. 解剖学杂志, 1994, 17(1): 56-59 |
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| 作者姓名： | 虞国茂 沈康 |
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| 作者单位： | 温州医学院组织胚胎学教研室 温州325003(虞国茂，沈康)，温州医学院附属二院 温州325003(郑锦华) |
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| 摘 要： | 孕鼠１６１只随机分组，在孕期第７－１１天给实验组分别以５００ｍｇ／（ｋｇ．ｄ）（蜈蚣１组）及１０００ｍｇ／（ｋｇ．ｄ）（蜈蚣２组）的中药蜈蚣煎剂灌胃，至孕期１８天记录各组孕鼠和胎鼠的发育情况。结果表明：蜈蚣１，２两组致畸作用明显，死胎，吸收胎比例升高；蜈蚣２组胎鼠和孕鼠的体重均下降，堕胎作用显著，与对照组比较，差异均有非常显著意义（Ｐ＜０．０１）。
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| 关 键 词： | 敌枯双 蜈蚣 胚胎 致畸作用 |
THE EFFECT OF SCOLOPENDRA DECOCTION ON EMBRYOS OF MICE |
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| Yu Guomao,Shen Kang,Zheng Jinhua. THE EFFECT OF SCOLOPENDRA DECOCTION ON EMBRYOS OF MICE[J]. Chinese Journal of Anatomy, 1994, 17(1): 56-59 |
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| Authors: | Yu Guomao Shen Kang Zheng Jinhua |
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| Affiliation: | Yu Guomao,Shen Kang,Zheng JinhuaDepartment of Histology and Embryology,Wenzhou Medical college 2nd Affilated Hospital Wenzhou 325003 |
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| Abstract: | One hundred and sixty-one pregnant mice were divided into several groups at random. 500 mg/ (kg.d) and 1000 mg (kg.d) scolopendra decoction were daily perfused into the stomach of the mice in Group I and Group II respectively from the 7th to the llth day after pregnancy. The development of the mice in different groups were recorded on the 18th day after pregnancy. The re-sults were as follows: the teratogenic effect on the pregnant mice in Group I and Group II were re-markable. The percentage of the dead embryos and the absorbed embryos were increased. In Group II, the body weight of the pregnant mice and of their embryos were reduced and the abortive ef-fect was obvious. As compared with the control group, the cifference was very significant (P<0.01). |
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| Keywords: | N. N'-methylene-bis (2-amino-l. 3. 4. thiadiazoie): Scolopendra. embryo teratogenic effect |
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