腹腔灌注顺铂射频热疗联合EF方案治疗晚期胃癌临床观察

目的:观察腹腔灌注顺铂(DDP)射频热疗联合静脉注射表阿霉素(EPI)、5氟尿嘧啶(5FU)治疗晚期胃癌的疗效及安全性。方法:共入组晚期胃癌56例,其中管状腺癌5例,低分化腺癌26例,黏液腺癌16例,印戒细胞癌9例,治疗方案为DDP40mg/m2加入44℃生理盐水1500～2000mL中,行腹腔灌注。然后腹腔射频热疗1.5h,温度42℃～43℃,d1、d8;EPI50mg/m2,静脉冲入,d1;5FU500mg/m2,静脉滴入6～8h,d1～d5。21d为1个周期,至少应用4～6个周期。结果:可评价疗效51例中,CR4例,PR25例,SD16例,PD6例,总有效率为56.9%(29/51),中位肿瘤进展时间5.3个月,中位生存期12.4个月,主要不良反应为骨髓抑制、恶心、呕吐。结论:腹腔灌注DDP射频热疗联合静脉注射EPI、5FU治疗晚期胃癌疗效较好,毒性可耐受。

Clinical study of intraperitoneal perfusion of cisplatin combined with radiofrequency hyperthermic plus epirubicin and fluorourracil in treatment of advanced stomach cancer

OBJECTIVE:To evaluate the efficacy and toxicity of intraperitoneal hyperthermic perfusion of cisplatin combined with radiofrequency plus epirubicin and fluorourracil in the treatment of advanced stomach cancer. METHODS: A total of 56 cases of advanced stomach cancer were treated with intraperitoneal hyperthermic perfusion of cisplatin (40 mg/m 2 on day 1,8 by infusion for 30 min) combined with radiofrequency plus epirubicin (50 mg/m 2 on d_1 by infusion) and fluorourracil (500 mg/m 2 on day 1-5 by infusion for 6 h). RESULTS: The overall response rate was 56.9%. The median time to progress was 5.3 months. Median survival time was 12.4 months. The main side effect included bone marrow suppression, nausea and vomiting. CONCLUSIONS: Intraperitoneal hyperthermic perfusion of cisplatin plus epirubicin and fluorourracil is effective in the treatment of advanced stomach cancer with an acceptable toxicity pattern.