| 十二指肠空肠旁路术治疗2型糖尿病的作用及机制 |
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| 引用本文： | 胡春晓,刘少壮,胡三元.十二指肠空肠旁路术治疗2型糖尿病的作用及机制[J].中华胃肠外科杂志,2014(7):635-638. |
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| 作者姓名： | 胡春晓 刘少壮 胡三元 |
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| 作者单位： | 山东大学齐鲁医院普通外科,济南250012 |
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| 基金项目： | 国家自然科学基金（81270888,81370496,81300286）;教育部博士点基金（20130131120069）;山东省博士点基金（BS2013YY031） |
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| 摘 要： | 2型糖尿病是最常见的威胁公众健康的慢性病之一.传统治疗控制血糖的方法效果较差.胃旁路术在治疗病态性肥胖的同时,可以快速、有效、长期地缓解其并发的2型糖尿病,但其机制目前仍不明确.十二指肠空肠旁路术是胃旁路术的一种改良术式,主要用来研究胃旁路术治疗2型糖尿病的机制,对非病态性肥胖的2型糖尿病患者的临床治疗也取得了一些初步的研究结果.本文对十二指肠空肠旁路术治疗2型糖尿病的效果及机制进行总结,以期对胃旁路术改善糖代谢的机制进行进一步的阐述,并对代谢手术治疗糖尿病的临床应用提供理论依据.
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| 关 键 词： | 2型糖尿病 胃旁路术 十二指肠空肠旁路术 胰岛素敏感性 |
Role and mechanism of duodenal-jejunal bypass in the management of type 2 diabetes mellitus |
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| Hu Chunxiao,Liu Shaozhuang,Hu Sanyuan.Role and mechanism of duodenal-jejunal bypass in the management of type 2 diabetes mellitus[J].Chinese Journal of Gastrointestinal Surgery,2014(7):635-638. |
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| Authors: | Hu Chunxiao Liu Shaozhuang Hu Sanyuan |
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| Institution: | (Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China) |
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| Abstract: | Type 2 diabetes mellitus （T2DM） is one of the most common chronic diseases and public health problems.Roux-en-Y gastric bypass （RYGB） can rapidly,effectively and sustainably improve glycemic control in morbidly obese patients with T2DM.However,the mechanisms of glycemic control after RYGB are still unclear now.Duodenal-jejunal bypass （DJB） is an improved RYGB sparing intact stomach,which is mainly used to investigate the mechanisms of RYGB to treat T2DM.DJB has also been used to treat nonobese T2DM patients.In the present article,we review the results and mechanisms of DJB to treat T2DM on the basis of the previous studies to further elucidate the mechanisms of RYGB in the management of T2DM. |
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| Keywords: | Type 2 diabetes mellitus Roux-en-Y gastric bypass Duodenal-jejunal bypass Insulin sensitivity |
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