胃转流术治疗2型糖尿病的机制

胃转流术是目前2型糖尿病外科治疗的主流术式之一,但其治疗2型糖尿病的相关机制并不完全清楚.现有的相关研究表明,胃转流术对2型糖尿病的治疗作用可能通过如下机制：摄入受限和吸收不良、胰岛素抵抗的改善和胰岛β细胞功能的恢复、胃肠道激素水平的变化等.此外,脂肪因子以及血清胆汁酸水平的变化也可能发挥了一定作用.下一步的研究需要进一步明确胃转流术对于机体神经内分泌系统的影响机制,并探讨胃转流术消化道重建方式对于相关激素的影响情况.

Possible mechanisms of Roux-en-Y gastric bypass treatment for type 2 diabetes mellitus

Roux-en-Y gastric bypass （RYGB） is a classic procedure for the treatment of type 2 diabetes mellitus （T2DM）,but it remains unclear why this procedure works.There might be several mechanisms that RYGB works through to treat T2DM,including calorie restriction and malabsorption,improvement of insulin resistance and β-cell functions,and altered secretion of gastrointestinal hormones.Altered levels of adipokines and serum bile acids might also play a role after RYGB.Future researches should concentrate on the exact mechanism of the altered hormone levels after RYGB,and whether different methods of gastrointestinal tract reconstruction could lead to various hormone levels.