壳聚糖纳米粒作为药物递送系统在癌症治疗中的应用

癌症是威胁人类生存的恶性疾病之一。近年来,利用纳米技术将药物靶向递送到肿瘤部位,可以增加疗效并降低毒性,为癌症治疗带来了新希望。壳聚糖是自然界唯一存在的碱性多糖,具有良好的生物相容性和生物可降解性。此外,其反应位点多,可制成不同性质的衍生物,广泛用于药物递送系统和组织工程支架,在生物医药领域具有重要的应用价值。本综述对近年来壳聚糖纳米粒在抗癌药物递送方面的研究进展进行介绍,重点介绍了壳聚糖纳米粒的制备、被动靶向、主动靶向和刺激-响应药物递送系统方面的研究进展。

Application of chitosan nanoparticle served as drug delivery system for cancer therapy

Cancer is one of the malignant diseases threatening human.In recent years,nanotechnology is becoming the hope the cancer treatment,as it can take the drugs targeting to tumor sites,with enhanced efficacy and reduced toxicity.Chitosan is the only alkaline polysaccharide in nature with good biocompatibility and biodegradability.Moreover,chitosan has many reaction sites to make derivatives with different properties.Chitosan and its derivatives are widely used for drug delivery systems and tissue engineering scaffolds.Hence,they are valuable in the field of biomedicine.In this paper,the recent advances chitosan nanoparticles as drug delivery system for delivering anticancer drugs are reviewed,especially the advances of the preparation,passive targeting,active targeting,and stimuli-responsive drug delivery systems of chitosan nanoparticles.