18F-FDG PET/CT诊断急性白血病髓外复发的临床价值

目的观察18氟-脱氧葡萄糖正电子发射计算机断层成像术(18F-FDG PET/CT)诊断急性白血病(AL)髓外复发的临床价值。方法对116例因临床怀疑复发而行18F-FDG PET/CT检查的AL患者临床资料进行回顾性分析。分析18F-FDG PET/CT对AL髓外复发的诊断价值。结果18F-FDG PET/CT诊断AL髓外复发灵敏度为91.18%、特异度为91.67%、准确度为91.38%、阳性预测值为93.94%、阴性预测值为88.00%,Kappa值为0.823。68例AL患者髓外复发,其中仅髓外复发47例,髓内、髓外均复发21例。18F-FDG PET/CT诊断62例真阳性患者共检出髓外器官或组织浸润152个,病灶平均SUVmax为6.43。结论18F-FDG PET/CT可以清晰显示AL髓外复发病灶的分布范围及FDG摄取程度,对AL髓外复发有较高的诊断价值。

Clinical Value of 18F-FDG PET/CT in the Diagnosis of Extramedullary Recurrence of Acute Leukemia

Objective To observe the clinical value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)in the diagnosis of extramedullary recurrence of acute leukemia(AL).Methods The clinical data of 116 patients with AL who underwent 18F-FDG PET/CT examination due to clinically suspected recurrence were retrospectively analyzed.The diagnostic value of 18F-FDG PET/CT for extramedullary recurrence of AL was analyzed.Results The sensitivity,specificity,accuracy,positive predictive value,negative predictive value and Kappa value of 18F-FDG PET/CT in the diagnosis of extramedullary recurrence of AL were 91.18%,91.67%,91.38%,93.94%,88.00%and 0.823.Sixty-eight cases of AL patients were with extramedullary recurrence,of which 47 cases were with only extramedullary recurrence,and 21 cases were with both intramedullary and extramedullary recurrence.A total of 152 extramedullary organs or tissue infiltration were detected among 62 cases of true positive patients by 18F-FDG PET/CT diagnosis,and the average SUVmax of the lesion was 6.43.Conclusion 18F-FDG PET/CT can clearly show the distribution range of AL extramedullary recurrence lesions and the degree of FDG uptake,and it has a high diagnostic value for extramedullary recurrence of AL.