MRI骶髂关节评分评估五藤治尪汤结合西药治疗强直性脊柱炎的效果观察

目的探究磁共振成像(MRI)骶髂关节评分评估五藤治尪汤结合西药治疗强直性脊柱炎的效果。方法将56例强直性脊柱炎患者随机分为对照组及研究组各28例,对照组以西药治疗,研究组以五藤治尪汤结合西药治疗,患者治疗前后均进行MRI检查,观察患者治疗前后临床疗效与加拿大脊柱关节炎研究协会MRI骶髂关节评分系统评价结果,分析MRI骶髂关节评分评估疗效的价值。结果两组患者临床评价[BASDAI、Bath AS功能指数(BASFI)、BASFI评分、C反应蛋白(CRP)、血沉(ESR)]指标水平及MRI SPARCC评分较治疗前均显著降低(P<0.05),且研究组低于对照组(P<0.05);治疗后,研究组患者临床治疗总有效率显著高于对照组(P<0.05);ROC曲线分析显示,MRI SPARCC评分评价五藤治尪汤结合西药治疗强直性脊柱炎ASAS 40标准疗效达标的曲线下面积为0.782(CI95%=0.591~0.976,P<0.05),评估敏感度84.61%,特异性75.00%。结论五藤治尪汤结合西药治疗强直性脊柱炎疗效显著,以MIR骶髂关节评分评估该方案疗效具有较高评估效能。

Obser vation on MRI Sacroiliac Joint Score in Evaluating the Effects of Wuteng Zhiwang Decoction Combined with Western Medicine on Ankylosing Spondylitis

Objective To explore the magnetic resonance imaging(MRI)sacroiliac joint score in evaluating the effects of Wuteng Zhiwang decoction combined with Western medicine on ankylosing spondylitis.Methods Fifty-six patients with ankylosing spondylitis were selected and randomly divided into the control and study groups,with 28 cases in each group.The control group was treated with Western medicine,and the study group was treated with Wuteng Zhiwang decoction combined with Western medicine,and the patients were given MRI examination before and after treatment.The clinical efficacy and evaluation results of Canadian Spinal Arthritis Research Association MRI sacroiliac joint scoring system were analyzed before and after treatment,and the value of MRI sacroiliac joint score in evaluating the efficacy was analyzed.Results The clinical evaluation indexes[Bath Ankylosing Spondylitis Disease Activity Score Index(BASDAI),Bath ankylosing spondylitis functional index(BASFI),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)]and MRI SPARCC score in the two groups were significantly lower than those before treatment(P<0.05),and the scores and levels in study group were lower than those in control group(P<0.05).After treatment,the total effective rate of clinical treatment in study group was significantly higher than that in control group(P<0.05).ROC curve analysis showed that the area under the curve of MRI SPARCC score was 0.782(CI95%=0.591~0.976,P<0.05)in evaluating the ASAS 40 standard efficacy of Wuteng Zhiwang decoction combined with Western medicine on ankylosing spondylitis,and the evaluation sensitivity and specificity were 84.61%and 75.00%.Conclusion Wuteng Zhiwang decoction combined with Western medicine has obvious efficacy on ankylosing spondylitis.MIR sacroiliac joint score has high efficiency in evaluating the efficacy of this regimen.