宫颈鳞状细胞癌组织中p63和p40的表达及其临床意义

目的探讨宫颈鳞状细胞癌组织中p63和p40的表达及其临床意义。方法选择宫颈鳞状细胞癌组织标本83例,采用免疫组织化学染色法检测p63和p40的表达,分析p63和p40在宫颈鳞状细胞癌中的表达状况,并分析宫颈鳞状细胞癌组织中p63和p40表达与患者临床病理特征的关系以及二者之间的相关性。结果在83例宫颈鳞状细胞癌组织中,呈p63弱阳性或阳性表达者65例,阳性率为78.31%,呈p40弱阳性或阳性表达者72例,阳性率为86.75%,二者均呈弱阳性或阳性表达者53例,阳性率为63.86%,二者均呈阴性表达者10例,阴性率为12.05%。不同年龄、部位的宫颈鳞状细胞癌患者组织中p63和p40的阳性表达无明显差异性(χ^2分别=1.17、1.75、0.52、0.71,P均>0.05),但不同肿瘤大小、临床分期、分化程度、肌层浸润深度及有无淋巴结转移、脉管浸润、宫旁浸润的患者组织中p63和p40的阳性表达存在显著性差异(χ^2分别=5.72、23.14、13.10、43.40、53.99、61.36、62.43、6.57、33.73、7.36、35.85、35.87、22.13、50.02,P均<0.05)。Pearson相关性分析显示,宫颈鳞状细胞癌组织中p63与p40的表达水平呈正相关(r=0.96,P<0.05)。结论p63和p40在宫颈鳞状细胞癌组织中具有较高的阳性表达率,与患者的疾病恶性程度有关,且二者表达呈正相关。

Expressions and clinical significance of p63 and p40 in cervical squamous cell carcinoma

Objective To investigate the expressions and clinical significance of p63 and p40 in cervical squamous cell carcinoma.Methods The expressions of p63 and p40 in 83 cases of cervical squamous cell carcinoma were detected by immunohistochemical staining.The relationship between the expressions of p63 and p40 in cervical squamous cell carcinoma and the clinicopathological characteristics was analyzed.Results In 83 cases of cervical squamous cell carcinoma,65 cases showed p63 weak positive or positive expression,the positive rate was 78.31%.Totally 72 cases showed p40 weak positive or positive expression,the positive rate was 86.75%.Totally 53 cases showed weak positive or positive expression,the positive rate was 63.86%.Both of p63 and p40 were negative in 10 cases,the negative rate was 12.05%.There was no significant difference in the expressions of p63 and p40 in different age and location of cervical squamous cell carcinoma(χ^2=1.17,1.75,0.52,0.71,P>0.05),but there were significant differences in the expressions of p63 and p40 in different tumor size,clinical stage,degree of differentiation,depth of myometrial invasion,lymph node metastasis,vascular invasion and parauterine invasion(χ^2=5.72,23.14,13.10,43.40,53.99,61.36,62.43,6.57,33.73,7.36,35.85,35.87,22.13,50.02,P<0.05).Pearson correlation analysis showed that the expression level of p63 and p40 in cervical squamous cell carcinoma was positively correlated(r=0.96,P<0.05).Conclusion The p63 and p40 have a high positive expression rate in cervical squamous cell carcinoma,which is related to the malignant degree of the disease,and they have a positive correlation.