基因多态性与非酒精性脂肪性肝病相关性研究

目的探讨PNPLA3 rs738409基因多态性与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)发生的关系。方法利用计算机在万方数据库、中国全文期刊数据库和维普数据库、Embase和Pubmed数据库中检索PNPLA3 rs738409基因多态性与NAFLD发生的相关文献,并应用RevMan 5.0软件对符合入选标准的文献进行异质性检验和效应值合并,同时进行敏感性分析和偏倚评估。结果纳入符合条件的相关文献11篇,共计NAFLD组1 069例,对照组2 127例。根据异质性检验结果,采用相应的效应模型进行合并分析。结果PNPLA3 rs738409位点GC、CC、GC+CC基因型与NAFLD的合并OR值(95%CI)分别为0.63(0.36¹.12)、0.22(0.111.12)、0.22(0.11⁰.43)、0.50(0.150.43)、0.50(0.15¹.66),Z=1.57、4.43、1.13,P>0.05、<0.05、>0.05。各研究的敏感性分析较稳定且无发表偏倚。结论 PNPLA3 rs738409 CC基因型与NAFLD的发生密切相关。

Meta- Analysis of PNPLA3 Gene Polymorphism and Non -Alcoholic Fatty Liver Disease

Objective To explore the relationship between patatin -like phospholipase domain containing3 （PNPLA3） rs738409 gene polymorphism and non - alcoholic fatty liver disease （NAFLD）. Methods The literature concerning PNPLA3 rs738409 gene polymorphism and non - alcoholic fatty liver disease was comprehensively retrieved in WanFang DATA , Chinese full - text journal databases, VIP database, Embase and Pubmcd database. The included literature was tested for heterogeneity, merging effect value, sensitivity analysis and bias evaluation with RevMan 5. 0 software. There were 11 pieces of literature included, which covered 1069 cases of NAFLD and 2127 cases of controls. The corresponding effect model was used for pooled analysis according to heterogeneity test results. Results For NAFLD, the pooled OR and 95% CI of gene type GC,CC,GC ＋ CC were 0.63（0.36 -1.12） （Z=1. 57, P 〉0.05）, 0.22（0.11 -0.43） （Z=4. 43, P 〈0.05）, and 0.50（0.15 - 1.66） （Z = 1.13, P 〉0.05） respectively. The sensitiveness analysis was stable and there was no publication bias. Conclusions PNPLA3 rs738409 CC gene type is closely related to the occurrence of NAFLD.