Ependymoma of the sella turcica: a variant of pituicytoma |
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Authors: | Scheithauer Bernd W Swearingen Brooke Whyte E Tessa Hedley Auluck Pavan K Stemmer-Rachamimov Anat O |
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Affiliation: | a Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA b Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02101, USA c Department of Surgery, Harvard Medical School, Boston, MA 02101, USA d Department of Neuropathology, Massachusetts General Hospital, Boston, MA 02101, USA e Department of Pathology, Harvard Medical School, Boston, MA 02101, USA |
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Abstract: | A broad spectrum of neoplasms affects the sellar region. Among these, gliomas are rare, most being tumors of pituicytes such as granular cell tumor and pituicytoma. Only 4 ependymomas of the human sellar region have been reported to date and all have had classic histologic features. Herein, we describe the clinicopathologic features of a sellar, low-grade ependymoma with unusual histology, but classic ultrastructural features, occurring in an elderly patient and thus expanding the spectrum of reported cases. The literature is reviewed and concepts of histogenesis are explored, particularly an origin in "ependymal pituicytes." The concept that sellar ependymoma is pituicyte-derived is explored. |
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Keywords: | Ependymoma Pituicytes Pituitary Sella turcica Immunohistochemistry Ultrastructure |
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