Elevated LDL Triglycerides and Atherosclerotic Risk |
| |
| Institution: | 1. Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark;2. The Copenhagen General Population Study, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark;3. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;4. MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom;5. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom;1. Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA;2. Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA;3. Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA;4. Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA;5. Minneapolis Heart Institute, Abbott Northwestern Hospital, and Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA;6. Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA;7. Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA;8. Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA;9. Department of Laboratory Medicine and Pathology, Hennepin Healthcare/HCMC, Minneapolis, Minnesota, USA;10. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA;11. Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, California, USA;12. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA;13. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA;14. Heart Failure and Biomarker Trials, Baim Institute for Clinical Research, Boston, Massachusetts, USA;1. Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa;2. Division of Cardiology, Department of Medicine, Groote Schuur Hospital, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa;3. Division of Cardio-Thoracic Sciences, Sindh Institute of Urology and Transplant, Karachi, Pakistan;4. South African Medical Research Council Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, Cape Town, South Africa;1. Metabolic Diseases Research Unit, National Institute for Medical Sciences and Nutrition Salvador Zubiran, Tlalpan, Mexico City, Mexico;2. Monterrey Institute of Technology and Higher Education, Xochimilco, Mexico City, Mexico;3. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, MN, USA;4. New Balance Foundation Obesity Prevention Center, Boston Children’s Hospital, Boston, MA, USA;5. Department of Pediatrics, Harvard Medical School, Boston, MA, USA;6. Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA |
| |
| Abstract: | BackgroundIt is unclear whether elevated low-density lipoprotein (LDL) triglycerides are associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD).ObjectivesThis study tested the hypothesis that elevated LDL triglycerides are associated with an increased risk of ASCVD and of each ASCVD component individually.MethodsThe study investigators used the Copenhagen General Population Study, which measured LDL triglycerides in 38,081 individuals with a direct automated assay (direct LDL triglycerides) and in another 30,208 individuals with nuclear magnetic resonance (NMR) spectroscopy (NMR LDL triglycerides). Meta-analyses aggregated the present findings with previously reported results.ResultsDuring a median follow-up of 3.0 and 9.2 years, respectively, 872 and 5,766 individuals in the 2 cohorts received a diagnosis of ASCVD. Per 0.1 mmol/L (9 mg/dL) higher direct LDL triglycerides, HRs were 1.26 (95% CI: 1.17-1.35) for ASCVD, 1.27 (95% CI: 1.16-1.39) for ischemic heart disease, 1.28 (95% CI: 1.11-1.48) for myocardial infarction, 1.22 (95% CI: 1.08-1.38) for ischemic stroke, and 1.38 (95% CI: 1.21-1.58) for peripheral artery disease. Corresponding HRs for NMR LDL triglycerides were 1.26 (95% CI: 1.20-1.33), 1.33 (95% CI: 1.25-1.41), 1.41 (95% CI: 1.31-1.52), 1.13 (95% CI: 1.05-1.23), and 1.26 (95% CI: 1.10-1.43), respectively. The foregoing results were not entirely statistically explained by apolipoprotein B levels. In meta-analyses for the highest quartile vs the lowest quartile of LDL triglycerides, random-effects risk ratios were 1.50 (95% CI: 1.35-1.66) for ASCVD (4 studies; 71,526 individuals; 8,576 events), 1.62 (95% CI: 1.37-1.93) for ischemic heart disease (6 studies; 107,538 individuals; 9,734 events), 1.30 (95% CI: 1.13-1.49) for ischemic stroke (4 studies; 78,026 individuals; 4,273 events), and 1.53 (95% CI: 1.29-1.81) for peripheral artery disease (4 studies; 107,511 individuals; 1,848 events).ConclusionsElevated LDL triglycerides were robustly associated with an increased risk of ASCVD and of each ASCVD component individually in 2 prospective cohort studies and in meta-analyses of previous and present studies combined. |
| |
| Keywords: | atherosclerosis cardiovascular disease lipids remnants triglyceride-rich lipoproteins very low-density lipoprotein ASCVD"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"atherosclerotic cardiovascular disease HDL"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"high-density lipoprotein ICD"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"International Classification of Diseases IDL"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"intermediate-density lipoprotein LDL"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"low-density lipoprotein NMR"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"nuclear magnetic resonance VLDL"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"very low-density lipoprotein |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
