Values of combined C-reactive protein,procalcitonin and serum amyloid A in differential diagnosis of bacterial and non-bacterial community acquired pneumonia in children |
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| Institution: | 1. Laboratoire Hospitalier Universitaire de Bruxelles, (LHUB-ULB) Department of Microbiology, Université Libre de Bruxelles, Brussels, Belgium;2. Department of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium;3. Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium;4. Gastroenterology Unit, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium;5. Gastroenterology Department, Centre Hospitalier Inter régional Edith Cavell, sites de la Basilique et E. Cavell, Brussels, Belgium;6. Gastroenterology Unit, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium;7. Belgian Helicobacter and Microbiota Study Group (BHMSG), Brussels, Belgium;1. Laboratory of Human and Experimental Pathology, Pasteur Institute of Tunis, Tunis, Tunisia;2. Laboratory of Molecular Epidemiology and Experimental Pathology, Pasteur Institute of Tunis, Tunis, Tunisia;3. High Institute of Sciences and Technology of Environments of Borj-Cedria, University of Carthage, Tunis, Tunisia;1. Laboratoire de Parasitologie-Mycologie, CHU Nîmes, Nîmes, France;2. Laboratoire de Parasitologie-Mycologie, CHU Nîmes, Université de Montpellier, CNRS, IRD, MiVEGEC, Montpellier, France;1. Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka;2. Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka;3. Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India;1. Department of Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan;2. Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan;3. Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;1. Facultad de Medicina, Unidad de Medicina Experimental, Universidad Nacional Autónoma de México, Mexico City, Mexico;2. Escuela de Ciencias de la Salud, Universidad del Valle de México, Campus Coyoacán, Mexico City, Mexico;3. Laboratorio de Microbiología, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico;4. Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Centro Médico Nacional Siglo XXI, Hospital de Pediatría, Instituto Mexicano del Seguro Social, Mexico City, Mexico;5. Hospital Civil de Guadalajara Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental, Guadalajara, Jalisco, Mexico |
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| Abstract: | This research aimed to explore the clinical value of C-reactive protein (CRP), procalcitonin (PCT), and serum amyloid A (SAA) in early diagnosis of bacterial pneumonia. CRP, PCT, and SAA levels of children with bacterial pneumonia, children with non-bacterial pneumonia, and healthy children were compared. The sensitivity and specificity of CRP, PCT, and SAA in the diagnosis of bacterial pneumonia in children were compared. CRP, PCT, and SAA levels were significantly lower in healthy children when compared with children with Community acquired pneumonia (CAP). ROC analyses showed that CRP, PCT, and SAA all had good accuracy in distinguishing bacterial pneumonia from non-bacterial pneumonia. The combination of CRP, PCT, and SAA further enhanced the accuracy in distinguishing bacterial pneumonia from non-bacterial pneumonia. In conclusion, the expression levels of CRP, PCT, and SAA could indicate the status of bacterial pneumonia. The combined test of CRP, PCT, and SAA had the highest diagnostic accuracy. |
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