替米沙坦对高血压病的疗效及对肱动脉内皮功能的影响

目的 观察替米沙坦对轻中度原发性高血压患者的降压疗效及其对肱动脉内皮功能的影响：方法 31例轻中度高血压患者（治疗组）应用替米沙坦治疗8周．20例健康志愿者为对照组，采用多普勒超声血管显像法测定两组对象肱动脉内皮依赖性血流介导的扩血管反应（FMD）。结果 治疗组应用替米沙坦8周后显著降压（P〈0．05）．降压总有效率71％，治疗组FMD显著低于对照组（P〈0．05），治疗组应用替米沙坦后FMD（flow—mediated dilation）与用药前比较显著提高（P〈0．05），但仍低于对照组（P〈0．05）。结论 替米沙坦具有降压．改善内皮功能的作用：

The effect of telmisartan on essential hypertension and its influence on endothelial function of brachial artery

Objective To observe the effect of Telmisartan on blood pressure and its influence on endothelial function of the brachial artery in patients with mild-to-moderate essential hypertension. Methods 31 patients with mild-to-moderate essential hypertension(the treatment group) had been treated with telmisartan for 8 weeks,and 20 healthy volunteers were collected as control(the control group).The flow-meditated-vasodilation of the brachial artery in 2 groups was measured by vascular Doppler ultrasonic technique. Results Blood pressure in the treatment group was significantly lowered after treatment than that before treatment(P<0.05).The total effective hypotensive rate was 71%.FMD in the treatment group before treatment with telmisartan was significantly lower than that in the control group(P<0.05).FMD in the treatment group after treatment with telmisartan was significantly higher than that in the treatment group before treatment with telmisartan(P<0.05),however,FMD in the treatment group after treatment with telmisartan was still lower than that in the control group(P<0.05). Conclusion Telmisartan can lower blood pressure and improve endothelial function.