伐地那非联合心理疗法治疗老年男性肾移植受者勃起功能障碍的疗效评价

目的：评估伐地那非联合心理疗法治疗老年男性肾移植受者勃起功能障碍（ED）的有效性及安全性。方法：随机选取50岁及以上、肾移植术后1年及以上和血肌酐150 μmol?L-1的肾移植受者120例，应用国际勃起功能指数（IIEF）进行肾移植术后性功能状况评分，存在ED者给予伐地那非联合心理治疗6个月，重新采用IIEF来评估其有效性。监测患者血清肌酐值、肌酐清除率、肝功能及免疫抑制剂（环孢素及普乐可复）浓度以评估伐地那非的安全性。结果：120例肾移植受者中78例存在ED。78例ED患者采用伐地那非联合心理治疗6个月后，IIEF评分由11.2±4.2升至23.3±4.6（P<0.05）；肾功能、肝功能及免疫抑制剂浓度在治疗前后无明显改变，无严重不良反应。结论：伐地那非联合心理疗法治疗老年男性肾移植术后ED有效且安全。

Evaluation of curative effect of vardenafil combined with mental intervention for erectile dysfunction in aged male kidney transplant recipients

Objective To evaluate the efficacy and safety of vandenafil combined with mental intervention in aged male kidney transplant recipients with erectile dysfunction (ED).Methods One hundred and twenty male patients (aged more than fifty years) who had received kidney transplantations at least one year before and whose serum IIEF questionnaire, and those with ED were treated with oral vardenafil combined with mental intervention for six months.The efficacy was assessed with IIEF. Its safety was appraised by measuring serum creatinine levels, creatinine clearances, liver function and concentrations of CSA and FK506. Results Seventy-eight aged men with ED received oral vardenafil combined with mental intervention for six months. IIEF score was improved from 11.2±4.2 (before treatment) to 23.3±4.6 (after treatment) (P<0.05);but renal function, liver function, FK506 and CSA concentrations remained unchanged.There were no significant adverse effects.Conclusion Oral vardenafil combined with mental intervention is effective and safe for the treatment of ED in aged male kidney transplant recipients.