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| 头孢地嗪对肺炎克雷伯杆菌诱导中性粒细胞功能的影响 | |
| 引用本文： | 宋卉,张艳美,董红梅,叶靖,钱元恕.头孢地嗪对肺炎克雷伯杆菌诱导中性粒细胞功能的影响[J].汕头大学医学院学报,2005,18(2):71-73. |
| 作者姓名： | 宋卉 张艳美 董红梅 叶靖 钱元恕 |
| 作者单位： | 1. 汕头大学医学院药理学教研室 2. 汕头大学医学院病理学教研室 3. 汕头大学医学院附属肿瘤医院检验科,广东,汕头,515041 |
| 摘 要： | 目的：观察头孢地嗪(CDZ)对肺炎克雷伯杆菌(Kle.p)感染小鼠中性粒细胞释放活性氧以及细胞凋亡的影响。方法：用硝基四氮唑蓝还原实验检测中性粒细胞呼吸爆发释放活性氧的变化；透射电镜观察细胞凋亡情况以及CDZ对上述指标的影响。结果：CDZ处理加强了小鼠感染3h后的呼吸爆发，12h后降低其呼吸爆发强度，24h后几乎回落至感染前水平；CDZ对未感染小鼠的呼吸爆发无明显影响；CDZ处理可抑制小鼠感染Kle．p 3h后中性粒细胞的凋亡。结论：CDZ对Kle．p感染诱导的小鼠中性粒细胞呼吸爆发有调节作用，并抑制中性粒细胞凋亡。 |
| 关 键 词： | 肺炎克雷伯杆菌 头孢地嗪 中性粒细胞功能 中性粒细胞凋亡 呼吸爆发 硝基四氮唑蓝 透射电镜观察 细胞释放 实验检测 调节作用 感染诱导 活性氧 小鼠 24h 抑制 |
| 文章编号： | 1007-4716(2005)02-0071-03 |
| 修稿时间： | 2005年3月31日 |
Effects of Cefodizime on Neutrophil in Klebsiella pneumoniae Infected Mice |
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| SONG Hui,ZHANG Yan-mei,DONG Hong-mei,YE Jing,Qian Yuan-shu.Effects of Cefodizime on Neutrophil in Klebsiella pneumoniae Infected Mice[J].Journal of Shantou University Medical College,2005,18(2):71-73. | |
| Authors: | SONG Hui ZHANG Yan-mei DONG Hong-mei YE Jing Qian Yuan-shu |
| Institution: | SONG Hui~1,ZHANG Yan_mei~1,DONG Hong_mei~2,YE Jing~3,QIAN Yuan_shu~1 |
| Abstract: | Objective:To study the effects of cefodizime(CDZ)on superoxide production and neutrophil apoptosis response to heat_killed Klebsiella pneumoniae(Kle.p)in mice.Methods:The effects of CDZ on superoxide production of neutrophil were detected by nitrobluetetrazolium test.Neutrophil apoptosis was investigated by transmission electron microscope.Results:Superoxide production of neutrophils was increased after Kle.p infection.CDZ enhanced it in the first 6 hours after infection.However,in the later stage of infection,CDZ reduced the production of superoxide in infected mice.CDZ inhibited neutrophil apoptosis 3 hours after Kle.p stimulation.Conclusion:CDZ upregulates superoxide production in early stage of Kle.p infection and downregulates it in the later stage, and also inhibits apoptosis of neutrophils. |
| Keywords: | cefodizime neutrophil superoxide apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |